Table 5 Clusters of the top 104 keywords

1

expression

758

1

2

risk

356

7

1

cancer

434

2

2

factor (igf)-i

261

10

1

gene-expression

245

11

2

insulin

216

14

1

cells

235

12

2

colorectal-cancer

190

18

1

growth

194

17

2

igfbp-3

174

22

1

proliferation

185

19

2

binding protein-3

162

25

1

carcinoma

172

23

2

serum

141

29

1

gene

164

24

2

igf-binding protein-3

133

31

1

activation

155

26

2

hormone

128

33

1

messenger-rna

153

27

2

plasma-levels

128

35

1

progression

138

30

2

serum-levels

110

36

1

survival

130

32

2

association

102

38

1

identification

128

34

2

postmenopausal women

97

40

1

pathway

100

39

2

women

97

41

1

lung-cancer

90

43

2

circulating levels

95

42

1

metastasis

89

44

2

factor system

83

49

1

differentiation

88

45

2

men

79

52

1

resistance

88

46

2

system

75

53

1

invasion

86

47

2

cancer risk

70

56

1

binding

85

48

2

colon-cancer

67

59

1

cancer cells

81

50

2

body-mass index

66

60

1

igf-ii

79

51

2

c-peptide

65

61

1

overexpression

74

54

2

disease

64

62

1

protein

71

55

2

physical-activity

64

64

1

phosphorylation

64

63

2

breast-cancer risk

61

66

1

down-regulation

60

68

2

factor-binding-proteins

58

72

1

kinase

60

69

2

prostate-cancer risk

58

73

1

therapy

60

70

2

i igf-i

57

75

1

in-vitro

59

71

2

cancer-risk

56

76

1

cancer-cells

57

74

2

obesity

54

79

1

cell-proliferation

56

77

2

factor binding-protein-3

52

81

1

adenocarcinoma

54

78

2

estrogen

50

83

1

marker

53

80

2

antigen

47

88

1

growth-factor

52

82

2

insulin-like-growth-factor-1

43

95

1

angiogenesis

49

84

3

receptor

266

8

1

migration

49

86

3

apoptosis

261

9

1

prognosis

48

87

3

prostate-cancer

220

13

1

family

45

91

3

factor-binding protein-3

215

15

1

tumors

45

92

3

breast-cancer cells

197

16

1

mechanisms

44

94

3

binding-proteins

182

20

1

proteins

43

96

3

inhibition

175

21

1

tumor

43

97

3

factor-i receptor

142

28

1

domain

41

98

3

epithelial-cells

108

37

1

growth-factor-ii

41

99

3

factor receptor

68

57

1

poor-prognosis

41

100

3

tumor-growth

68

58

1

transcription

41

101

3

transgenic mice

63

65

1

hepatocellular-carcinoma

40

103

3

signaling pathways

61

67

1

p53

40

104

3

fibroblasts

49

85

2

growth-factor-i

425

3

3

induction

46

89

2

igf-i

410

4

3

death

45

90

2

factor-i

397

5

3

cell-lines

44

93

2

breast-cancer

370

6

3

carcinoma cells

40

102