Fig. 15
From: Expression characteristics and their functional role of IGFBP gene family in pan-cancer
The expression levels of IGFBP2 protein in gastric cancer tissues and adjacent normal tissues. A The expression levels of IGFBP2 protein in gastric tissues by IHC staining: (A-1) Gastric pit tissue (200x), the arrow indicates the negative staining of IGFBP2 protein in gastric pit cell. (A-2) Normal gastric antrum tissue (200x), the arrow indicates the positive staining of IGFBP2 protein in gastric antrum cell. (A-3) Moderately differentiated GC tissue (200x), the arrow indicates the negative staining of IGFBP2 protein in GC cell. (A-4) Gastric signet ring cells carcinoma (200x), the arrow indicates the negative staining of IGFBP2 protein in signet ring cell. (A-5) GC tissue and adjacent normal gastric tissue (100x), the solid arrows indicate the negative staining of IGFBP2 protein in GC cells, and the dotted arrow indicates the positive staining of IGFBP2 protein in normal gastric cell. B Statistical quantification of the HSCORE of IGFBP2 staining in the indicated tissues: (B-1) The protein expression level of IGFBP2 in adjacent normal gastric tissues was significantly higher than that in GC tissues. (B-2) In the paired GC tissues and adjacent normal tissues, the protein expression of IGFBP2 in the normal tissues was significantly higher. GC, gastric cancer; HSCORE, histological score