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Fig. 5 | BMC Cancer

Fig. 5

From: Single-cell transcriptome analysis profiles the expression features of TMEM173 in BM cells of high-risk B-cell acute lymphoblastic leukemia

Fig. 5

TMEM173 expression was related to functional activation of DCs in the BM of B-ALL. A-C. Transcriptional features of TMEM173 in DCs from healthy donors. DCs were isolated from healthy BM cells. (A) Clustering identified 11 clusters of DCs. (B) T-SNE plots profiled the expression of typical marker genes (LYZ, CTSS, and IRF7) and TMEM173. (C) Ridge plots compared the expression levels of TMEM173 with immuno-activating markers (CD86, CD83, and ITGAE). D-G. Transcriptional features of TMEM173 in DCs from B-ALL patients. DCs were isolated from patients’ BM cells. (D) Clustering identified 8 clusters of DCs. (E) T-SNE plots profiled the expression of typical marker genes (CDKN1C, VCAN, and IRF7) and TMEM173. (F) Ridge plots compared the expression levels of TMEM173 with immuno-activating markers (CD86, ITGAE, and CXCR4). (G) Pseudo-time analysis profiled the expression trajectory of TMEM173 during the development of DCs. The arrow represented the direction of development.

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BMC Cancer

ISSN: 1471-2407

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