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Fig. 4 | BMC Cancer

Fig. 4

From: Single-cell transcriptome analysis profiles the expression features of TMEM173 in BM cells of high-risk B-cell acute lymphoblastic leukemia

Fig. 4

TMEM173 expression was associated with cytotoxic activity of NK cells in the BM of B-ALL. A-C. Transcriptional features of TMEM173 in NK cells from the BM of healthy donors. NK cells were isolated from healthy BM cells. (A) Clustering identified 3 clusters of NK cells. (B) T-SNE plots profiled the expression of typical marker genes (CD56, CD16, GNLY, TRAC, and GZMK) and TMEM173. (C) Ridge plots compared the expression levels of TMEM173 with specific biomarkers, including CD56, CD160, TIGIT, GZMK, and DUSP2. D-F. Transcriptional features of TMEM173 in NK cells from B-ALL patients. NK cells were isolated from patients’ BM cells. (D) Cell clustering identified 6 clusters of NK cells. (E) T-SNE plots profiled the expression of typical marker genes (CD56, CD16, IL2RB, GZMA, and GZMB) and TMEM173. (F) Ridge plots compared the expression levels of TMEM173 with activation biomarkers, including CD56, CXCR4, IL2RB, GZMA, and GZMB.

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BMC Cancer

ISSN: 1471-2407

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