Increased prevalence of the founder BRCA1 c.5309G>T and recurrent BRCA2 c.1310_1313delAAGA mutations in breast cancer families from Northerstern region of Morocco: evidence of geographical specificity and high relevance for genetic counseling

Table 4 Breast cancer BRCA mutations prediction with the Eisinger model

Mutations	Mean score	Median score	Range score	P value (M-U_test)
*BRCA1* c.5309G>T
Positive (n = 10)	7.4 ± 1.18	7	2–16	*0.002*
Negative (n = 166)	4.02 ± 0.20	3	0–13	*0.002*
*BRCA2* c.1310_1313 DelAAGA
Positive (n = 8) ^a	5.63 ± 0.65	5.5	3–9	*0.02*
Negative (n = 126)	4.02 ± 0.25	3	0–16	*0.02*
Both mutations
Positive (n = 18)	6.61 ± 0.73	6	2–16	*0.00012*
Negative (n = 159)	3.92 ± 0.21	3	0–13	*0.00012*

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