Table 3 Comparaison of clinicopathological features by germline BRCA1 c.5309G > T and BRCA2 c.1310_1313 DelAAGA mutations in female BC of northeastern Morocco
| Â | BRCA1 c.5309G>T mutation | BRCA2 c.1310_1313 DelAAGA mutation | ||||
|---|---|---|---|---|---|---|
Neg (n = 174) | Pos (n = 10) |  | Neg (n = 132) | Pos (n = 12) |  | |
Characteristics | n (%) | n (%) | pa | n (%) | n (%) | pa |
Age at diagnosis | ||||||
 Mean (years ± SD) | 42.2 ± 9.62 | 41 ± 6.02 | 0.799 | 43.96 ± 9.89 | 38.5 ± 8.92 | 0.09 |
  ≤ 39 | 70 (41.9) | 4 (40) |  | 47 (37) | 6 (60) |  |
  > 39 | 97 (58.1) | 6 (60) | 1 | 80 (63) | 4 (40) | 0.185 |
 unknown | 7 | 0 |  | 5 | 2 |  |
Family history of BCb | ||||||
 Sporadic | 91 (54.8) | 1 (10) |  | 74 (58.7) | 3 (30) |  |
 Familial | 75 (45.2) | 9 (90) | 0.007 | 52 (41.3) | 7 (70) | 0.1 |
Laterality | ||||||
 Bilateral | 6 (3.6) | 2 (20) |  | 8 (6.3) | 0 (0) |  |
 Unilateral | 161 (96.4) | 8 (80) | 0.067 | 119 (93.7) | 10 (100) | 1 |
Histological type | ||||||
 Ductal invasive | 140 (83.8) | 8 (80) |  | 108 (85) | 8 (80) |  |
 Lobular invasive | 16 (9.6) | 1 (10) | 1 | 11 (8.7) | 1 (10) | 1 |
 others | 11 (6.6) | 1 (10) | 0.51 | 8 (6.3) | 1 (10) | 0.5 |
Histological grade | ||||||
 I + II | 125 (75.3) | 8 (80) |  | 97 (77) | 6 (60) |  |
 III | 41 (24.7) | 2 (20) | 1 | 29 (23) | 4 (40) | 0.256 |
RE | ||||||
 Positive | 120 (72.7) | 6 (60) |  | 89 (71.2) | 8 (80) |  |
 Negative | 45 (27.3) | 4 (40) | 0.47 | 36 (28.8) | 2 (20) | 0.725 |
RP | ||||||
 Positive | 109 (66.1) | 6 (60) |  | 83 (66.4) | 6 (60) |  |
 Negative | 56 (33.9) | 4 (40) | 0.74 | 42 (33.6) | 4 (40) | 0.735 |
Her-2 | ||||||
 Positive | 34 (21.2) | 0 (0) |  | 24 (19.8) | 0 (0) |  |
 Negative | 126 (78.8) | 10 (100) | 0.21 | 97 (80.2) | 9 (100) | 0.209 |
Sub-Type | ||||||
 Luminal | 97 (60.6) | 5 (50) | Ref | 75 (62) | 7 (77.8) | Ref |
 Her-2 +  | 33 (20.6) | 0 (0) | 0.33 | 23 (19) | 0 (0) | 0.343 |
 Triple Negative | 30 (18.8) | 5 (50) | 0.12 | 23 (19) | 2 (22.2) | 1 |
Tumor size | ||||||
 T1 | 33 (20.2) | 2 (22.2) | 1 | 28 (22.8) | 3 (30) | 0.722 |
 T2 | 95 (58.3) | 5 (55.6) | Ref | 68 (55.3) | 6 (60) | Ref |
 T3-T4 | 35 (21.5) | 2 (22.2) | 1 | 27 (22) | 1 (10) | 0.67 |
Node | ||||||
 N +  | 120 (72.3) | 5 (55.6) |  | 87 (69.6) | 9 (90) |  |
 N0 | 46 (27.7) | 4 (44.4) | 0.28 | 38 (30.4) | 1 (10) | 0.28 |
Metastase | ||||||
 M0 | 143 (86.1) | 8 (80) |  | 105 (82.7) | 10 (100) |  |
 M +  | 23 (13.9) | 2 (20) | 0.64 | 22 (17.3) | 0 (0) | 0.365 |