Table 2 Clinical and pathological characteristics of BRCA1 c.5309G>T and BRCA2 c.1310_1313 DelAAGA mutation carriers in Moroccan population
Patient | Age at diagnosis | Laterality | Tumor Type | Histological grade | ER PR Her-2 status | TNM | Sub-type | Family history | Predicted BRCA mutation Riska |
|---|---|---|---|---|---|---|---|---|---|
BRCA1 c.5309G>T mutation | Â | ||||||||
 1 | 36 | unilateral | IDC | II |  +  + - | pT2 N0 M0 | luminal | Twin sister (33 y); 2 cousins (34 y) | 7 |
 2 | 34 | bilateral | IDC | III | - - - | M +  | TN | Sister (OC); Father (BC); 3 sisters; 2 cousins | 16 |
 3 | 42 | unilateral | IDC | I |  +  + - | pT1 N + M0 | luminal | 2 sisters died | 6 |
 4 | 50 | bilateral | IDC/IMC | III |  +  + - | pT2 N + M0 | luminal | Aunt; cousin (OC) | 6 |
 5 | 46 | unilateral | ILC | II | - - - | pT2 N0 M0 | TN | Sister (30 y); cousin (30 y); cousin (28 y) | 8 |
 6 | 33 | unilateral | IDC | II | - - - | pT2 N + M0 | TN | Twin sister (36 y); 2 cousins (34 y) | 7 |
 7 | 42 | unilateral | IDC | II | - - - | pT3N + M0 | TN | Sister (29 y); sister (40 y) | 8 |
 8 | 49 | unilateral | IDC | II | - - - | pT2 N0 M0 | TN | Sister; 3 nieces | 10 |
 9 | 37 | unilateral | IDC | II |  + - - | pT1 N0 M0 | luminal | Cousin (34 y) | 4 |
 10 | 41 | unilateral | IDC | II |  +  + - | pT3 N + M1 | luminal | No family history | 2 |
BRCA2 c.1310_1313 DelAAGA mutation | Â | ||||||||
 11 | 32 | unilateral | IDC/ILC | II |  +  + - |  | luminal | Aunt died | 3 |
 12 | 30 | unilateral | IDC | III |  + - - | pT2N + M0 | luminal | Sister; 3 nieces | 9 |
 13 | 37 | unilateral | ILC | II |  +  + -   | pT2N + M0 | NA | Sister; M. cousin | 4 |
 14 | 45 | unilateral | IDC | II | - - - | pT2N + M0 | TN | Sister (31 y); M. and P. cousin | 6 |
 15 | 30 | unilateral | IDC | II |  +  + - | pT1N + M0 | luminal | Sister (43 y); aunt (50 y) | 5 |
 16 | 28 | unilateral | IDC | II |  +  + - | pT1N + M0 | luminal | Aunt (OC) | 7 |
 17 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
 18 | 47 | unilateral | IDC | III |  +  + - | pT2N + M0 | luminal | Sisters; aunt; cousin (43 y) | 6 |
 19 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
 20 | 36 | unilateral | IDC | I | - - - | pT2N + M0 | TN | Aunt (young); cousin | 5 |
 21 | 54 | unilateral | IDC | III |  +  + - | pT2N + M0 | luminal | NA | NA |
 22 | 46 | unilateral | IDC | III |  + - - | pT1N0M0 | luminal | NA | NA |
 1 (male) | 65 | unilateral | IDC | II |  +  + - | pT2N + M0 | luminal | Sister; 3 nieces died (BC) | 8 |
 2 (male) | 71 | unilateral | IDC | II |  +  + - | pT2N + M0 | luminal | 3 nieces | 7 |