Table 1 Comparison of clinicopathological features between familial and sporadic patients groups
Patients Groups | Familial | Sporadic | Â |
|---|---|---|---|
Clinical featuresb | N (%) | N (%) | Pa |
Age at diagnosis | |||
 Mean (years ± SD) | 38,58 ± 0.95 | 45.62 ± 0.95 |  < 10–6 |
 (Min–Max) | (25–71) | (30–72) | |
  ≤ 39 | 47 (55.3) | 28 (28.9) |  |
  > 39 | 38 (44.7) | 69 (71.1) | 0.0003 |
BRCA1 c.5309G>T | |||
 Positive | 9 (10.7) | 1 (1.1) | 0.007 |
 Negative | 75 (89.3) | 91 (98.9) | |
BRCA2 c.1310_1313 DelAAGA | |||
 Positive (total: 12)*** | 7 (11.9) | 3 (3.9) | 0.1 |
 Negative | 52 (88.1) | 74 (96.1) | |
Both mutations | |||
 Positive (total: 22)*** | 16 (19) | 4 (4.2) | 0.002 |
 Negative | 68 (81) | 91 (95.8) | |
Laterality | |||
 Bilateral | 8 (9.4) | 0 (0) |  |
 Unilateral | 77 (90.6) | 97 (100) | 0.002 |
Histological type | |||
 Ductal invasive | 71 (83.5) | 83 (85.6) |  |
 Lobular invasive | 8 (9.4) | 9 (9.3) | 0.86 |
 others | 6 (7.1) | 5 (5.2) |  |
Histological grade | |||
 I + II | 59 (69.4) | 79 (82.3) |  |
 III | 26 (30.6) | 17 (17.7) | 0.04 |
RE | |||
 Positive | 63 (75) | 67 (69.8) |  |
 Negative | 21 (25) | 29 (30.2) | 0.44 |
RP | |||
 Positive | 59 (70.2) | 59 (61.5) |  |
 Negative | 25 (29.8) | 37 (38.5) | 0.22 |
Her-2 | |||
 Positive | 17 (21.5) | 18 (18.8) |  |
 Negative | 62 (78.5) | 78 (81.2) | 0.65 |
Sub-Type | |||
 Luminal | 44 (55.7) | 63 (65.6) |  |
 Her-2 +  | 16 (20.3) | 18 (18.8) | 0.31 |
 Triple Negative | 19 (24.0) | 15 (15.6) |  |
Tumor size | |||
 T1 | 20 (24.1) | 17 (18.1) |  |
 T2 | 53 (63.9) | 51 (54.3) | 0.03 |
 T3-T4 | 10 (12) | 26 (27.7) |  |
Node | |||
 N +  | 54 (64.3) | 76 (79.2) |  |
 N0 | 30 (35.7) | 20 (20.8) | 0.026 |
Metastase | |||
 M0 | 80 (95.2) | 74 (77.1) |  |
 M +  | 4 (4.8) | 22 (22.9) | 0.001 |