Fig. 4
From: SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway
SLC27A2 regulated the function and number of peroxisomes in colorectal cancer. A ~ B The function and number of peroxisomes were enhanced, and the uptake levels of fluorescent FA (BODIPY FL C16, PA, 10 μM) were elevated and the colocalization of FA with peroxisomes were enhanced when SLC27A2 was overexpressed in CRC. C ~ D The function and number of peroxisomes, uptake level of fluorescent FA, and colocalization diminished when SLC27A2 was knocked down in CRC. NC: negative control; OE: over expression; PMP70: belonged to the superfamily of ATP-binding cassette (ABC) transporters, also named ABCD3 (ATP Binding Cassette Subfamily D Member 3)