Table 1 Outcomes and their Operationalization

Total medication quality

Total FORTA score

x

x

Medication underuse

FORTA medication underuse sub-score

x

x

Medication overuse

FORTA medication overuse sub-score

x

x

PIM use

FORTA PIM use sub-score

x

x

Global health status

EORTC-QLQ-C30 questions: 29 + 30

x

x (primary)

x

Physical functioning

EORTC-QLQ-C30 questions: 1–5

x

x

x

Role functioning

EORTC-QLQ-C30 questions: 6,7

x

x

x

Emotional functioning

EORTC-QLQ-C30 questions: 21–24

x

x

x

Cognitive functioning

EORTC-QLQ-C30 questions: 20,25

x

x

x

Social functioning

EORTC-QLQ-C30 questions: 26,27

x

x

x

Dyspnoea

EORTC-QLQ-C30 question: 8

x

x

x

Pain

EORTC-QLQ-C30 questions: 9, 19

x

x

x

Insomnia

EORTC-QLQ-C30 question: 11

x

x

x

Appetite loss

EORTC-QLQ-C30 question: 13

x

x

x

Nausea and vomiting

EORTC-QLQ-C30 questions: 14,15

x

x

x

Constipation

EORTC-QLQ-C30 question: 16

x

x

x

Diarrhoea

EORTC-QLQ-C30 question: 17

x

x

x

Dizziness

Self-developed

Fatigue

EORTC-QLQ-C30 questions: 10,12,18

x

x

x

Physical fatigue

EORTC-FA12

questions: 1–5

x

x

x

Emotional fatigue

EORTC-FA12

questions: 6–8

x

x

x

Cognitive fatigue

EORTC-FA12

questions: 9–10

x

x

x

Interference of fatigue with daily life

EORTC-FA12

question: 11

x

x

x

Frailty

FRAIL-SCALE

x

Falls

Frequency, self-reported

x

Hospitalizations

Frequency, self-reported

x

All-cause mortality

All deaths

x

Cancer mortality

ICD-10 codes C00-C97

x

Non-cancer mortality

All ICD-10 codes except C00-C97

x