Table 3 Univariate and multivariate Cox regression analysis of risk factors associated with disease-free survival

SPRYD4 expression (Low vs. High)

5.83

4.16–7.50

< 0.01

2.89

1.98–3.80

< 0.01

Gender (Male vs. Female)

1.32

0.29–2.35

0.75

Age (≧50 vs. < 50)

1.26

0.41–2.11

0.83

CA19-9 (≧300 kU/L vs. < 300 kU/L)

2.34

1.26–3.42

< 0.05

1.63

0.84–2.42

0.26

Lymphnodes metastasis (Positive vs. Negative)

1.51

0.62–2.40

0.43

Lymphovascular invasion (Positive vs. Negative)

2.97

2.15–3.79

< 0.01

1.65

0.98–2.82

0.06

TNM stage (Advanced vs. Early)

4.09

2.89–5.29

< 0.01

2.41

1.37–3.45

< 0.05

Differentiation (Poor vs. Well)

2.07

1.19–2.95

< 0.05

1.43

0.61–2.12

0.41