Table 2 Univariate and multivariate Cox regression analysis of risk factors associated with overall survival

SPRYD4 expression (Low vs. High)

6.81

5.23–8.39

< 0.01

3.29

1.85–4.73

< 0.01

Gender (Male vs. Female)

1.72

0.83–2.61

0.25

Age (≧50 vs. < 50)

1.31

0.34–2.28

0.67

CA19-9 (≧300 kU/L vs. < 300 kU/L)

2.09

1.14–3.04

< 0.05

1.62

0.78–2.46

0.31

Lymphnodes metastasis (Positive vs. Negative)

2.96

1.99–3.93

< 0.01

2.09

1.22–2.96

< 0.05

Lymphovascular invasion (Positive vs. Negative)

1.51

0.42–2.60

0.58

TNM stage (Advanced vs. Early)

4.57

3.34–5.8

< 0.01

2.97

2.03–3.91

< 0.01

Differentiation (Poor vs. Well)

2.04

1.11–2.97

< 0.05

1.24

0.56–1.92

0.42