Table 2 Clinicopathologic characteristics of included studies for the meta-analyses
Reference | Year | The number of harvested LNs | The number of metastatic LNs | UICC/AJCC TNM | Follow − up(mouth) | Follow-up | Cutoff | Groups in the study | NOS score | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LODDS0 | LODDS1 | LODDS2 | LODDS3 | LODDS4 | |||||||||
Gu P [11] | 2021 | Median (range): 58.3 (15–89) | Median (range): 2.0 (0–84) | the 8th edition | Median (range): 87 (2 − 186) | 5-year OS | LODDS 0 (LODDS ≤ -1.5) LODDS 1 (-1.5 < LODDS ≤ -1.0) LODDS 2 (-1.0 < LODDS ≤ -0.5) LODDS 3 (-0.5 < LODDS ≤ 0) LODDS 4 (LODDS > 0) | 1992 | 1567 | 1474 | 1409 | 1178 | 8 |
Pan S [23] | 2019 | Median (IQR): 21 (13–32) | Median (IQR): 1 (0–4) | the 8th edition | Median (IQR): 36.0 (1 − 426) | 5-year OS | LODDS 0 (LODDS ≤ -1.5) LODDS 1 (-1.5 < LODDS ≤ -1.0) LODDS 2 (-1.0 < LODDS ≤ -0.5) LODDS 3 (-0.5 < LODDS ≤ 0) LODDS 4 (LODDS > 0) | 506 | 443 | 324 | 303 | 154 | 8 |
Cao H [24] | 2019 | - | - | the 8th edition | - | 5-year OS | LODDS 0 (LODDS ≤ -0.5) LODDS 1 (-0.5 < LODDS ≤ 0) LODDS 2 (0 < LODDS ≤ 0.5) LODDS 3 (LODDS > 0.5) | 261 | - | 160 | 312 | 144 | 7 |
Toth D [25] | 2017 | mean (range): 10.48 (1–38) | mean (range): 3.22 (0–23) | the 6th, the 7th, and the 8th edition | Median (range): 23.0 (3–136) | 5-year OS | LODDS 0 (LODDS < –1.125) LODDS 1 (–1.125 ≤ LODDS < –0.25) LODDS 2 (–0.25 ≤ LODDS < 0.75) LODDS 3 (LODDS ≥ 0.75) | 29 | - | 75 | 43 | 17 | 8 |
Lee JW [34] | 2016 | mean ± SD: 41.2 ± 16.5 | mean ± SD: 3.22 ± 6.8 | the 7th edition | Median: 69.7 | 5-year OS | LODDS 0 (LODDS ≤ -4) LODDS 1 (-4 < LODDS ≤ -2.5) LODDS 2 (-2.5 < LODDS ≤ -2) LODDS 3 (-2.5 < LODDS ≤ -2) LODDS 4 (LODDS > -0.5) | 1850 | 996 | 226 | 609 | 248 | 8 |
Jian-Hui C [35] | 2016 | mean (range): 24.9 (0–140) | mean (range): 4.61 (0 − 124) | the 7th edition | Median (range): 53.3 (1.3–148.4) | 5-year OS | LODDS 0 (LODDS ≤ -1.5) LODDS 1 (-1.5 < LODDS ≤ -1.0) LODDS 2 (-1.0 < LODDS ≤ -0) LODDS 3 (LODDS > 0) | 277 | 170 | 385 |  | 103 | 6 |
Spolverato G [15] | 2015 | Median (IQR): 17 (11–25) | - | the 7th edition | Median: 21 | 5-year OS | LODDS 0 (LODDS ≤ -1.5) LODDS 1 (-1.5 < LODDS ≤ -1.0) LODDS 2 (-1.0 < LODDS ≤ -0.5) LODDS 3 (-0.5 < LODDS ≤ 0) LODDS 4 (LODDS > 0) | 459 | 61 | 63 | 87 | 132 | 8 |
Aurello P [36] | 2014 | mean (range): 26.4 (3 − 73) | mean (range): 6.9 (0–59) | the 7th edition | Median: 77 | 5-year OS | LODDS 0 (LODDS < -1.0) LODDS 1 (-1.0 ≤ LODDS < -0.5) LODDS 2 (-0.5 ≤ LODDS < 0) LODDS 3 (0 ≤ LODDS < 0.5) LODDS 4 (LODDS ≥ 0.5) | 88 | 27 | 31 | 19 | 12 | 8 |
Xu J [12] | 2013 | - | - | the 7th edition | Median (range): 55 (39–81) | 5-year OS | LODDS 0 (LODDS < -1.0) LODDS 1 (-1.0 ≤ LODDS < -0.5) LODDS 2 (-0.5 ≤ LODDS < 0) LODDS 3 (0 ≤ LODDS < 0.5) LODDS 4 (LODDS ≥ 0.5) | 129 | 87 | 85 | 76 | 50 | 8 |
Liu H [37] | 2013 | Median (range): 21 (15 − 66) | Median (range): 3 (0–21) | the 7th edition | Median (range): 52 (3–89) | 5-year OS | LODDS 0 (LODDS < -1.5) LODDS 1 (-1.5 ≤ LODDS < -1.0) LODDS 2 (-1.0 ≤ LODDS < -0.5) LODDS 3 (LODDS ≥ -0.5) | 100 | 64 | 71 | 137 |  | 8 |
Qiu MZ [38] | 2012 | Median (range): 16 (0 − 72) | Median (range): 4 (0–70) | the 7th edition | Median (range): 48 (3 − 175) | 5-year OS | LODDS 0 (LODDS < -0.5) LODDS 1 (-0.5 ≤ LODDS < 0) LODDS 2 (0 ≤ LODDS < 0.5) LODDS 3 (LODDS ≥ 0.5) | 305 | 174 |  | 142 | 109 | 8 |
Sun Z [14] | 2010 | - | - | the 6th edition | Median (range): 41 (3 − 332) | 5-year OS | LODDS 0 (LODDS ≤ -1.5) LODDS 1 (-1.5 < LODDS ≤ -1.0) LODDS 2 (-1.0 < LODDS ≤ -0.5) LODDS 3 (-0.5 < LODDS ≤ 0) LODDS 4 (LODDS > 0) | 544 | 594 | 533 | 528 | 348 | 8 |