Table 1 Clinical characteristics of patients with HCC who underwent adjuvant TACE or not
Clinical characteristics | Before PSM | After PSM | |||||||
|---|---|---|---|---|---|---|---|---|---|
Total (n = 1491) | Adjuvant TACE | P | Total (n = 1254) | Adjuvant TACE | P | ||||
No (n = 709) | Yes (n = 782) | No (n = 627) | Yes (n = 627) | ||||||
Age (years) | 56.00 (47.00, 64.00) | 57.00 (48.00, 66.00) | 55.00 (47.00, 63.00) | 0.007 | 56.00 (47.00, 64.00) | 56.00 (47.00, 65.00) | 56.00 (48.00, 64.00) | 0.908 | |
AFP (ng/mL) | 53.05 (6.30, 879.63) | 38.40 (5.00, 526.68) | 77.200 (7.68, 1000.00) | 0.003 | 47.38 (6.00, 718.00) | 38.66 (5.01, 620.10) | 67.50 (7.05, 812.75) | 0.107 | |
ALT (U/L) | 30.80 (22.00, 45.66) | 29.00 (21.00, 43.00) | 32.86 (23.00, 48.00) | 0.001 | 30.00 (21.20, 44.58) | 29.00 (21.05, 44.00) | 31.00 (21.45, 44.90) | 0.238 | |
AST (U/L) | 35.00 (26.99, 50.00) | 33.21 (26.00, 46.82) | 37.00 (28.00, 52.97) | < 0.001 | 34.00 (26.00, 48.00) | 33.21 (26.00, 46.73) | 34.55 (26.58, 50.00) | 0.106 | |
GGT (U/L) | 53.00 (30.14, 104.31) | 53.47 (30.00, 104.90) | 52.59 (30.53, 104.00) | 0.608 | 50.06 (29.01, 99.11) | 54.63 (30.24, 106.50) | 46.54 (29.00, 92.00) | 0.083 | |
ALP (U/L) | 96.00 (75.00, 123.00) | 93.00 (72.00, 122.55) | 98.13 (77.29, 124.80) | 0.034 | 95.00 (75.00, 122.97) | 93.23 (73.42, 122.90) | 96.50 (76.71, 122.94) | 0.327 | |
TB (mol/L) | 14.60 (10.80, 19.77) | 14.10 (10.40, 19.80) | 14.80 (11.19, 19.68) | 0.106 | 14.40 (10.70, 19.74) | 14.20 (10.40, 19.77) | 14.60 (11.07, 19.63) | 0.236 | |
WBC (10 9 /L) | 5.30 (4.27, 6.53) | 5.24 (4.22, 6.59) | 5.34 (4.33, 6.50) | 0.738 | 5.30 (4.30, 6.50) | 5.30 (4.33, 6.65) | 5.30 (4.26, 6.44) | 0.346 | |
CR (µmol/L) | 72.80 (62.40, 82.90) | 72.70 (62.40, 82.95) | 72.86 (62.45, 82.86) | 0.829 | 73.00 (63.00, 83.00) | 73.00 (62.45, 82.64) | 73.10 (63.13, 83.35) | 0.453 | |
PT (s) | 11.90 (11.30, 12.60) | 11.90 (11.30, 12.60) | 11.90 (11.30, 12.60) | 0.892 | 11.90 (11.30, 12.60) | 11.90 (11.30, 12.60) | 11.90 (11.30, 12.70) | 0.700 | |
NLR | 2.20 (1.61, 3.22) | 2.20 (1.59, 3.12) | 2.22 (1.62, 3.28) | 0.194 | 2.22 (1.61, 3.23) | 2.24 (1.60, 3.22) | 2.20 (1.62, 3.26) | 0.678 | |
LMR | 3.42 (2.59, 4.77) | 3.50 (2.59, 4.90) | 3.40 (2.59, 4.72) | 0.687 | 3.45 (2.60, 4.85) | 3.47 (2.56, 4.89) | 3.44 (2.64, 4.83) | 0.495 | |
PLR | 110.20 (82.18, 153.29) | 104.20 (78.01, 148.57) | 113.51 (86.96, 158.14) | < 0.001 | 109.78 (82.30, 150.50) | 107.20 (80.34, 150.00) | 111.71 (85.50, 151.93) | 0.153 | |
Operation time (mins) | 220.00 (165.00, 280.00) | 215.00 (160.00, 270.00) | 220.00 (176.25, 280.00) | 0.044 | 220.00 (170.00, 280.00) | 220.00 (165.00, 280.75) | 220.00 (175.00, 280.00) | 0.680 | |
Maximum tumor diameter (mm) | 44.00 (27.00, 71.00) | 40.00 (25.00, 65.00) | 49.00 (29.25, 76.00) | < 0.001 | 43.00 (27.00, 68.00) | 43.00 (27.00, 69.00) | 43.000 (27.00, 67.50) | 0.934 | |
Gender [n(%)] | male | 1263 (84.71) | 600 (84.63) | 663 (84.78) | 0.991 | 1064 (84.85) | 534 (85.17) | 530 (84.53) | 0.813 |
female | 228 (15.29) | 109 (15.37) | 119 (15.22) | 190 (15.15) | 93 (14.83) | 97 (15.47) | |||
HBV [n(%)] | Negative | 199 (13.35) | 107 (15.09) | 92 (11.76) | 0.070 | 169 (13.48) | 94 (14.99) | 75 (11.96) | 0.137 |
Positive | 1292 (86.65) | 602 (84.91) | 690 (88.24) | 1085 (86.52) | 533 (85.01) | 552 (88.04) | |||
Child–Pugh classification [n(%)] | A | 1424 (95.51) | 673 (94.92) | 751 (96.04) | 0.362 | 1199 (95.61) | 596 (95.06) | 603 (96.17) | 0.408 |
B | 67 (4.49) | 36 (5.08) | 31 (3.96) | 55 (4.39) | 31 (4.94) | 24 (3.83) | |||
Liver cirrhosis [n(%)] | No | 373 (25.02) | 178 (25.11) | 195 (24.94) | 0.988 | 306 (24.40) | 155 (24.72) | 151 (24.08) | 0.844 |
Yes | 1118 (74.98) | 531 (74.89) | 587 (75.06) | 948 (75.60) | 472 (75.28) | 476 (75.92) | |||
Number of tumors [n(%)] | single | 1307 (87.66) | 630 (88.86) | 677 (86.57) | 0.207 | 1104 (88.04) | 556 (88.68) | 548 (87.40) | 0.542 |
multiple | 184 (12.34) | 79 (11.14) | 105 (13.43) | 150 (11.96) | 71 (11.32) | 79 (12.60) | |||
Tumor location [n(%)] | left | 472 (31.66) | 232 (32.72) | 240 (30.69) | 0.648 | 402 (32.06) | 207 (33.01) | 195 (31.10) | 0.768 |
right | 945 (63.38) | 444 (62.62) | 501 (64.07) | 793 (63.24) | 391 (62.36) | 402 (64.11) | |||
double | 74 (4.96) | 33 (4.65) | 41 (5.24) | 59 (4.70) | 29 (4.63) | 30 (4.78) | |||
Tumor margin [n(%)] | Non-smooth | 376 (25.22) | 181 (25.53) | 195 (24.94) | 0.839 | 313 (24.96) | 161 (25.68) | 152 (24.24) | 0.602 |
Smooth | 1115 (74.78) | 528 (74.47) | 587 (75.06) | 941 (75.04) | 466 (74.32) | 475 (75.76) | |||
Vascular invasion (imaging) [n(%)] | Negative | 1362 (91.35) | 653 (92.10) | 709 (90.66) | 0.372 | 1161 (92.58) | 575 (91.71) | 586 (93.46) | 0.281 |
Positive | 129 (8.65) | 56 (7.90) | 73 (9.34) | 93 (7.42) | 52 (8.29) | 41 (6.54) | |||
Anatomical liver resection [n(%)] | No | 457 (30.65) | 245 (34.56) | 212 (27.11) | 0.002 | 384 (30.62) | 208 (33.17) | 176 (28.07) | 0.058 |
Yes | 1034 (69.35) | 464 (65.44) | 570 (72.89) | 870 (69.38) | 419 (66.83) | 451 (71.93) | |||
Laparoscopic surgery [n(%)] | No | 898 (60.23) | 422 (59.52) | 476 (60.87) | 0.632 | 735 (58.61) | 365 (58.21) | 370 (59.01) | 0.819 |
Yes | 593 (39.77) | 287 (40.48) | 306 (39.13) | 519 (41.39) | 262 (41.79) | 257 (40.99) | |||
MVI [n(%)] | Negative | 839 (56.27) | 450 (63.47) | 389 (49.74) | < 0.001 | 741 (59.09) | 372 (59.33) | 369 (58.85) | 0.909 |
Positive | 652 (43.73) | 259 (36.53) | 393 (50.26) | 513 (40.91) | 255 (40.67) | 258 (41.15) | |||
Satellite nodules [n(%)] | Negative | 1268 (85.04) | 607 (85.61) | 661 (84.53) | 0.607 | 1072 (85.49) | 527 (84.05) | 545 (86.92) | 0.173 |
Positive | 223 (14.96) | 102 (14.39) | 121 (15.47) | 182 (14.51) | 100 (15.95) | 82 (13.08) | |||
Differentiation [n(%)] | High-medium | 1231 (82.56) | 604 (85.19) | 627 (80.18) | 0.013 | 1038 (82.78) | 528 (84.21) | 510 (81.34) | 0.204 |
low | 260 (17.44) | 105 (14.81) | 155 (19.82) | 216 (17.22) | 99 (15.79) | 117 (18.66) | |||
CNLC stage [n(%)] | I | 1259 (84.43) | 615 (86.74) | 644 (82.35) | 0.026 | 1077 (85.89) | 540 (86.12) | 537 (85.65) | 0.162 |
II | 103 (6.91) | 37 (5.22) | 66 (8.44) | 84 (6.70) | 35 (5.58) | 49 (7.81) | |||
III a | 129 (8.65) | 57 (8.04) | 72 (9.21) | 93 (7.42) | 52 (8.29) | 41 (6.54) | |||