Table 4 Multivariate Analyses of overall survival for patients with advanced non-small cell lung cancer: age < 70 years versus ≥70 years
|  | Age <70 years (n = 1691) | Age ≥70 years (n = 1634) | ||
|---|---|---|---|---|
| Â | HR (95% CI) | p-value | HR (95% CI) | p-value |
Diagnosis Age 2009 2011 2015 2017 | Reference 0.89 (0.76–1.03) 0.82 (0.71–0.95) 0.88 (0.75–1.02) | 0.121 0.008 0.085 | Reference 1.00 (0.86–1.18) 0.97 (0.84–1.13) 0.87 (0.75–1.02) | 0.958 0.714 0.082 |
Sex Male versus Female | 1.28 (1.16–1.42) | < 0.001 | 1.15 (1.04–1.28) | 0.008 |
ECOG at Diagnosis PS 0–1 PS ≥2 Unknown | Reference 2.00 (1.79–2.23) 2.13 (1.80–2.51) | < 0.001 | Reference 2.14 (1.89–2.41) 1.86 (1.56–2.22) | < 0.001 |
SCS ≥9 versus < 9 | 1.05 (0.94–1.18) | 0.364 | 0.96 (0.86–1.08) | 0.964 |
Smoking History Never Current/Former Unknown | Reference 1.55 (1.34–1.80) 1.72 (1.09–2.70) | < 0.001 0.019 | Reference 1.53 (1.30–1.81) 1.66 (1.21–2.28) | < 0.001 0.002 |