Improved uptake and survival with systemic treatments for metastatic non-small cell lung cancer: younger versus older adults

Table 3 Multivariate analysis of systemic therapy uptake in adults age < 70 years and ≥ 70 years

	Age < 70 years		Age ≥ 70 years
	OR (95% CI)	p-value	OR (95% CI)	p-value
Sex Male Female	REFERENCE 1.20 (0.97–1.48)	0.094	REFERENCE 0.83 (0.65–1.06)	0.143
ECOG 0–1 ≥2 Unknown	REFERENCE 0.21 (0.15–0.30) 0.84 (0.60–1.17)	< 0.001 0.292	REFERENCE 0.13 (0.08–0.21) 0.58 (0.356–0.91)	< 0.001 0.017
SCS <9 ≥9	REFERENCE 0.69 (0.54–0.87)	0.002	REFERENCE 0.80 (0.61–1.05)	0.109
Year 2009 2011 2015 2017	REFERENCE 1.47 (1.08–2.01) 1.02 (0.77–1.36) 1.10 (0.83–1.44)	0.016 0.884 0.520	REFERENCE 1.67 (1.15–2.42) 1.44 (1.03-2.00) 1.17 (0.87–1.57)	0.007 0.033 0.372
Smoking Never Current/Former Unknown	REFERENCE 0.25 (0.10–0.63) 0.77 (0.31–1.92)	0.004 0.579	REFERENCE 0.19 (0.08–0.49) 0.46 (0.19–1.14)	< 0.001 0.093

OR = Odds Ratio; CI = Confidence Interval; ECOG = Eastern Cooperative Oncology Group; SCS = Simplified Comorbidity Score

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