Table 2 Univariate and multivariate Cox analysis of patients with stage III-IV LCNEC

Age

  ≥ 70 vs < 70

1.32 (1.1,1.59)

0.002

1.51 (1.25,1.83)

 < 0.001

Sex

 Male vs Female

1.12 (0.95,1.34)

0.183

-

-

Race

 Others vs Black

1.21 (0.72,2.04)

0.464

-

-

 White vs Black

1.15 (0.89,1.48)

0.277

-

-

T stage

 T1 vs T0

1.67 (0.83,3.35)

0.151

2.13 (1.05,4.32)

0.036

 T2 vs T0

1.93 (0.98,3.78)

0.056

2.11 (1.07,4.17)

0.032

 T3 vs T0

1.95 (0.99,3.84)

0.054

2.21 (1.11,4.42)

0.024

 T4 vs T0

2.22 (1.13,4.37)

0.02

2.83 (1.42,5.62)

0.003

N stage

 N1 vs N0

1.08 (0.76,1.53)

0.662

1.07 (0.75,1.52)

0.728

 N2 vs N0

1.14 (0.91,1.42)

0.251

1.39 (1.1,1.74)

0.005

 N3 vs N0

1.28 (0.98,1.68)

0.066

1.35 (1.02,1.78)

0.033

M stage

 M1 vs M0

1.86 (1.54,2.26)

 < 0.001

1.46 (1.14,1.86)

0.002

Stage

 IV vs III

1.86 (1.54,2.26)

 < 0.001

-

-

Bilaterality

 Yes vs No

0.93 (0.38,2.27)

0.87

-

-

Bone metastasis

 Yes vs No

2.01 (1.62,2.49)

 < 0.001

1.56 (1.23,1.97)

 < 0.001

Liver metastasis

 Yes vs No

2.11 (1.7,2.62)

 < 0.001

1.64 (1.29,2.09)

 < 0.001

Lung metastasis

 Yes vs No

1.64 (1.28,2.11)

 < 0.001

1.11 (0.84,1.46)

0.459

Brain metastasis

 Yes vs No

1.49 (1.23,1.8)

 < 0.001

1.53 (1.24,1.9)

 < 0.001