Table 5 Genotype-dependent ERAP1 mRNA expression levels as well as HWE test and \(f\) measure of locus deviation from Hardy–Weinberg equality

SNP

ERAP1 expression

Genotype

CC

GC

GG

rs26653 G > C

n

1

15

19

%

2.9

42.9

54.3

Non-tumor

Median^a

1.33^d

0.74

CI95%^b

0.94; 1.69

0.47; 1.00

Difference

d = 0.59

CI95% (0.14; 1.05), p = 0.0086

Tumor

Median^a

0.94^d

0.78

CI95%^b

0.46; 1.56

0.49; 1.07

Difference

d = 0.09

CI95% (− 0.40; 0.68), p = 0.7248

HWE test^c

\(\chi 2\)= 0.96, p = 0.32;\(f\)= − 0.17, CI95% (− 0.4; 0.12)

rs26618 T > C

ERAP1 expression

Genotype

CC

TC

TT

n

2

13

20

%

5.7

37.1

57.1

Non-tumor

Median

1.11

0.90

CI95%

0.75; 1.46

0.57; 1.23

Difference

d = 0.21

CI95% (− 0.28; 0.66), p = 0.3874

Tumor

Median

0.82

0.84

CI95%

0.41; 1.46

0.52; 1.18

Difference

d =  − 0.03

CI95% (− 0.53; 0.50), p = 0.9156

HWE test

\(\chi 2\)= 0.00, p = 0.9372,\(f\)= − 0.01, CI95% (− 0.32; 0.34)

rs2287987 T > C

ERAP1 expression

Genotype

CC

TC

TT

n

1

16

14

%

3.2

51.6

45.2

Non-tumor

Median

0.88

1.16

CI95%

0.53; 1.26

0.79; 1.54

Difference

d =  − 0.28

CI95% (− 0.81; 0.25), p = 0.2848

Tumor

Median

0.67

1.08

CI95%

0.37; 0.98

0.59; 1.69

Difference

d =  − 0.36

CI95% (− 1.00; 0.19), p = 0.2224

HWE test

\(\chi 2\)=1.98, p = 0.1616,\(f\)= − 0.25, CI95% (− 0.51; 0.06)

rs30187 C > T

ERAP1 expression

Genotype

TT

CT

CC

n

3

16

16

%

8.6

45.7

45.7

Non-tumor

Median

1.13

0.83

CI95%

0.79; 1.47

0.52; 1.16

Difference

d = 0.30

CI95% (− 0.16; 0.77), p = 0.2138

Tumor

Median

0.99

0.66

CI95%

0.60; 1.49

0.35; 0.99

Difference

d = 0.30

CI95% (− 0.15; 0.82), p = 0.2132

HWE test

\(\chi 2\)=0.13, p = 0.7375,\(f\)= − 0.06, CI95% (− 0.37; 0.27)

rs27044 C > G

ERAP1 expression

Genotype

GG

CG

CC

n

1

14

19

%

2.9

41.2

55.9

Non-tumor

Median

0.92

1.00

CI95%

0.56; 1.28

0.67; 1.36

Difference

d =  − 0.09

CI95% (− 0.58; 0.42), p = 0.7392

Tumor

Median

0.95

0.70

CI95%

0.47; 1.56

0.44; 0.96

Difference

d = 0.19

CI95% (− 0.30; 0.80), p = 0.4736

HWE test

\(\chi 2\)=0.71, p = 0.3891,\(f\)= − 0.14, CI95% (− 0.39; 0.14)