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Table 2 Comparison of patientsā€™ characteristics

From: Clinical benefit of subsequent chemotherapy after drug-induced interstitial lung disease in pancreatic cancer patients: a multicenter retrospective study from Japan

Ā 

S-1

nā€‰=ā€‰13

FOLFOX

nā€‰=ā€‰4

p-value

Age (year-old)

70.5 (45ā€“76)

67 (57ā€“74)

0.61

Sex (male:female)

11:2

2:2

0.21

Tumor stage (cStage III: IV)

5:8

1:3

1.00

ECOG PS (0:1)

13:0

4:0

1.00

Smoking history, n (%)

7 (54.0)

2 (50.0)

1.00

Brinkman index

960 (500ā€“1530)

470 (200ā€“740)

0.50

History of lung disease, n (%)

0 (0)

0 (0)

1.00

Presence of emphysema on CT scan, n (%)

3 (23.0)

1 (25.0)

1.00

Treatment, 1st line, n (%)

11 (84.6)

4 (100.0)

1.00

CEA (ng/mL)

6.6 (2.8ā€“48.5)

2.6 (1.3ā€“6.3)

0.06

CA19-9 (U/mL)

73.9 (2.1ā€“1990.0)

352.7 (130.4ā€“4819)

0.11

KL-6 (U/mL)

393.0 (187.0-1597.0)

271.5 (249.0-355.0)

0.13

SP-D (ng/mL)

183.9 (88.0-442.4)

322.0 (145.7-530.2)

0.34

ILD grade 1/2/3/4, n (%)

6 (46.2)/4 (30.8)/3 (23.1)/0

1 (25.0)/2 (50.0)/1 (25.0)/0

0.71

Steroid therapy, n (%)

3 (23.0)

2 (50.0)

0.53

  1. ECOG PS Eastern Cooperative Oncology Group Performance Status, CEA carcinoembryonic antigen, CA19-9 cancer antigen 19ā€‰āˆ’ā€‰9, KL-6 Krebs von den Lungen-6 antigen, SP-D surfactant protein D