Fig. 4

Distribution of TP53 exon mutation events and prognostic significance of disruptive mutation of TP53 in HPSCC patients (A) Histogram of number of cases with TP53 mutations by TP53 codon position and the top 4 most frequently mutated TP53 codons located in the DNA-binding domain in HPSCC patients. Kaplan-Meier estimates of (B) OS and (C) RFS among the 33 HPSCC patients with HPV(-)/TP53^{disruptive mut} and the 6 HPSCC patients with HPV(-)/TP53^{non-disruptive mut}. p=0.0492 for OS, p=0.0411 for RFS (Log-rank test)