Fig. 7
From: CA916798 predicts poor prognosis and promotes Gefitinib resistance for lung adenocarcinoma
Targeting CA916798 enhances Gefitinib inhibitory effects on LUAD cells
Schematic diagram of CA916798-mediated progression and Gefitinib resistance of LUAD. In normal lung epithelial cells, promoter of CA916798 gene is hypermethylated and the transcription level of CA916798 is low, which leads to suppression of CDK1 by WEE1 and cell cycle arrest (left panel). In LUAD cells, promoter of CA916798 gene is hypomethylated and the transcription level of CA916798 is dramatically elevated. In this context, CA916798 blocks the inhibition of CDK1 by WEE1 and facilitates cell cycle progression, resulting in LUAD progression and Gefitinib resistance (right panel)