Relationship between tumor microbiota transcriptional activity and gene expression in breast cancer

Liu, Enuo; Zhang, Fan; Xu, Tiansheng; Ye, Luyi; Ma, Sean Si Qian; Ji, Zai-Si

doi:10.1186/s12885-023-10726-4

BMC Cancer

Table 3 Gene expression positively correlated to Lactobacillus abundance and negatively correlated to Bacteroides abundance in ER-negative tumor tissues (r > 0.7 and p < 0.05)

From: Relationship between tumor microbiota transcriptional activity and gene expression in breast cancer

Gene Symbol	Taxonomy 1	Correlation Coefficient	P value	Taxonomy 2	Correlation Coefficient	P value	Description
IL5RA				Lactobacillus	0.92	0.000001	interleukin 5 receptor, alpha
VN1R66P				Lactobacillus	0.92	0.000001	vomeronasal 1 receptor 66 pseudogene
KRTAP10-2				Lactobacillus	0.91	0.000002	keratin associated protein 10 − 2
CCDC34	Bacteroides	-0.92	0.000001	Lactobacillus	0.89	0.000009	coiled-coil domain containing 34
C1orf68				Lactobacillus	0.89	0.000012	chromosome 1 open reading frame 68
BRD1	Bacteroides	-0.85	0.000073	Lactobacillus	0.85	0.00005	bromodomain containing 1
TRGVB	Bacteroides	-0.89	0.000009	Lactobacillus	0.85	0.000057	T-cell receptor gamma variable B (pseudogene)
OGFOD2				Lactobacillus	0.84	0.000076	2-oxoglutarate and iron-dependent oxygenase domain containing 2
PRCC	Bacteroides	-0.84	0.000096	Lactobacillus	0.84	0.000082	papillary renal cell carcinoma (translocation-associated)
TBL2				Lactobacillus	0.84	0.000086	actin, beta-like 2
ANAPC4				Lactobacillus	0.84	0.000104	anaphase promoting complex subunit 4
SIRPD				Lactobacillus	0.83	0.000121	signal-regulatory protein delta
PLA2G2E	Bacteroides	-0.77	0.000821	Lactobacillus	0.83	0.000135	phospholipase A2, group IIE
MALL				Lactobacillus	0.83	0.000143	mal, T-cell differentiation protein-like
ERC1				Lactobacillus	0.83	0.000147	ELKS/RAB6-interacting/CAST family member 1
PYCR1				Lactobacillus	0.82	0.000163	pyrroline-5-carboxylate reductase 1
CGB1				Lactobacillus	0.82	0.000205	chorionic gonadotropin, beta polypeptide 1
KRTAP5-8				Lactobacillus	0.81	0.000228	keratin associated protein 5–8
HIST2H2BE	Bacteroides	-0.94	0.0000002	Lactobacillus	0.80	0.000357	histone cluster 2, H2be
CRKL	Bacteroides	-0.85	0.000050	Lactobacillus	0.76	0.000989	v-crk avian sarcoma virus CT10 oncogene homolog-like
CCND1	Bacteroides	-0.84	0.000080	Lactobacillus	0.76	0.000935	cyclin D1
CDC42	Bacteroides	-0.72	0.002428	Lactobacillus	0.72	0.002575	cell division control protein 42 homolog
LTBR	Bacteroides	-0.71	0.002741	Lactobacillus	0.74	0.001720	lymphotoxin beta receptor (TNFR superfamily, member 3)
HIST2H2BF	Bacteroides	-0.71	0.002930	Lactobacillus	0.70	0.003442	histone cluster 2, H2bf
SHC1	Bacteroides	-0.87	0.00026	Lactobacillus	0.71	0.003305	SHC (Src homology 2 domain containing) transforming protein 1

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ISSN: 1471-2407

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