Table 2 Inclusion/Exclusion criteria

Diagnosis of carcinoma of the larynx (except T1-T2 N0 of the glottis), pharynx, oral cavity, salivary gland, paranasal sinuses, or cervical metastasis of unknown origin in stages I-II-III-IVa-IVb

Decompensated heart disease, uncontrolled hypertension (SBP > 200 or DAT > 110), heart failure (NYHA > I), or constrictive pericarditis

Radiotherapy (with or without concomitant chemotherapy) preceded or not by surgical treatment and performed with radical intent

Medical contraindication against exercise (such as bone fractures, tendon ruptures, spondylolisthesis > 25% with neurological compromise, rhabdomyolysis, herniated disc in the spine with neurological symptoms, cardiovascular comorbidities such as unstable angina, current myocarditis or thrombophlebitis); Neutropenia (< 500 mm3), severe anaemia (Hb < 8.0 g/dl), platelet count < 50.000 microL

 > 18 years

Radiotherapy with palliative intent

BMI > 18.5

Pregnancy

ECOG 0–1 or Karnofsky Index ≥ 80%

Regular physical activity (150 min/week of moderate activity or 75 min/week of vigorous activity, including two or more weekly strength training sessions), as measured by the PVS questionnaire

Signed consent form

Carcinoma of the glottis (T1-T2, N0)