Fig. 5

Inference of tumor-macrophage interactions. a-b Dot plot illustrating the ligand-receptor pairs with significant meaning for tumor-macrophage interaction across the cell compartments of PDAC. Macrophages were considered as receptor cells (panel a) or donor cells (panel b) as shown above. P-values are indicated by circle size; The means of the average expression level of interacting molecule 1 in cluster 1 and its interacting molecule 2 in cluster 2 are indicated by color. c Kaplan-Meier curves of overall survival in different groups of PDAC patients stratified by the median expression level of the ligand and receptor. P < 0.05 was identified as significant