Fig. 3

Identification of master regulatory networks across macrophage subsets. a Heatmap showing the normalized activity score of representative regulons across different macrophage subsets. b t-SNE plots based on activity score of 94 regulons and colored by annotations inferred from whole transcriptome profiling. c t-SNE plots showing activities of IRF1, STAT3, EZH2, KLF5, TCF4, and HES4 regulons. *g included in the parenthesis represents the number of genes in the regulons. PC, principal component; AUC, the area under the curve