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Table 3 Univariable and multivariable analyses for OS in the training cohort

From: A novel preoperative inflammation score system established for postoperative prognosis predicting of intrahepatic cholangiocarcinoma

 

Univariable

Multivariable

Variables

HR

95%CI

P value

HR

95%CI

P value

Age, year

1.005

0.993–1.017

0.453

   

Sex, male vs. female

1.055

0.808–1.377

0.694

   

Hepatolithiasis, yes vs. no

1.266

0.824–1.945

0.282

   

Diabetes, yes vs. no

0.921

0.555–1.530

0.751

   

HBsAg (+), yes vs. no

0.816

0.633–1.052

0.116

   

Anti-HCV, yes vs. no

0.749

0.239–2.343

0.619

   

Child-Pugh grade, B vs. A

0.446

0.143–1.394

0.165

   

TBIL, mg/dL

0.999

0.993–1.005

0.761

   

ALT, IU/L

1.001

0.999–1.002

0.081

   

AST, IU/L

1.001

1.000-1.002

0.042

   

GGT, IU/L

1.001

1.000-1.002

0.011

   

HgB, g/L

0.991

0.984–0.998

0.009

   

PT, second

1.058

0.956–1.172

0.274

   

ALB, g/L

0.950

0.92–0.981

0.002

   

PLT, ×109/L

1.002

1.000-1.003

0.034

   

WBC, ×109/L

1.075

1.014–1.139

0.015

   

AFP, µg/L

1.000

0.999–1.001

0.615

   

CEA, µg/L

1.000

0.999–1.001

0.142

   

CA19-9, IU/mL

1.001

1.000-1.002

< 0.001

1.000

1.0001–1.001

0.010

Perioperative transfusion, yes vs. no

1.354

0.974–1.883

0.071

   

Anatomic resection, yes vs. no

1.704

1.175–2.472

0.005

1.578

1.085–2.295

0.017

Major resection, yes vs. no

1.553

1.186–2.033

0.001

   

Resection margin < 10 mm, yes vs. no

1.833

1.134–2.963

0.012

   

Cirrhosis, yes vs. no

0.854

0.623–1.171

0.327

   

Tumor diameter, cm

1.117

1.074–1.162

< 0.001

   

Multiple tumors, yes vs. no

0.816

0.433–1.538

0.530

   

Satellite nodules, yes vs. no

1.997

1.537–2.595

< 0.001

1.448

1.095–1.915

0.009

Tumor capsule, yes vs. no

0.620

0.421–0.914

0.016

   

Tumor differentiation,

high vs. median vs. low

1.410

0.809–2.458

0.225

   

Adjacent tissue invasion, yes vs. no

1.570

0.944–2.611

0.082

   

MVI, yes vs. no

1.794

1.254–2.566

0.001

1.587

1.101–2.291

0.014

LNM, yes vs. no

2.179

1.618–2.935

< 0.001

1.422

1.038–1.949

0.028

IFS, high vs. median vs. low

2.320

1.955–2.753

< 0.001

2.106

1.682–2.637

< 0.001

  1. Abbreviations: HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; TBIL, total bilirubin; ALB, albumin; ALT, alanine transaminase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transpeptidase; PT, prothrombin time; PLT, platelet; AFP, alpha-fetoprotein; CEA, carcinoembryonic antigen; CA19-9, carbonhydrateantigen19-9; MVI, microvascular invasion; LNM, lymph node metastasis; IFS, inflammation score
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BMC Cancer

ISSN: 1471-2407

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