| Univariable | Multivariable | ||||
---|---|---|---|---|---|---|
Variables | HR | 95%CI | P value | HR | 95%CI | P value |
Age, year | 1.005 | 0.993–1.017 | 0.453 |  |  |  |
Sex, male vs. female | 1.055 | 0.808–1.377 | 0.694 |  |  |  |
Hepatolithiasis, yes vs. no | 1.266 | 0.824–1.945 | 0.282 |  |  |  |
Diabetes, yes vs. no | 0.921 | 0.555–1.530 | 0.751 |  |  |  |
HBsAg (+), yes vs. no | 0.816 | 0.633–1.052 | 0.116 |  |  |  |
Anti-HCV, yes vs. no | 0.749 | 0.239–2.343 | 0.619 |  |  |  |
Child-Pugh grade, B vs. A | 0.446 | 0.143–1.394 | 0.165 |  |  |  |
TBIL, mg/dL | 0.999 | 0.993–1.005 | 0.761 |  |  |  |
ALT, IU/L | 1.001 | 0.999–1.002 | 0.081 |  |  |  |
AST, IU/L | 1.001 | 1.000-1.002 | 0.042 | Â | Â | Â |
GGT, IU/L | 1.001 | 1.000-1.002 | 0.011 | Â | Â | Â |
HgB, g/L | 0.991 | 0.984–0.998 | 0.009 |  |  |  |
PT, second | 1.058 | 0.956–1.172 | 0.274 |  |  |  |
ALB, g/L | 0.950 | 0.92–0.981 | 0.002 |  |  |  |
PLT, ×109/L | 1.002 | 1.000-1.003 | 0.034 |  |  |  |
WBC, ×109/L | 1.075 | 1.014–1.139 | 0.015 |  |  |  |
AFP, µg/L | 1.000 | 0.999–1.001 | 0.615 |  |  |  |
CEA, µg/L | 1.000 | 0.999–1.001 | 0.142 |  |  |  |
CA19-9, IU/mL | 1.001 | 1.000-1.002 | < 0.001 | 1.000 | 1.0001–1.001 | 0.010 |
Perioperative transfusion, yes vs. no | 1.354 | 0.974–1.883 | 0.071 |  |  |  |
Anatomic resection, yes vs. no | 1.704 | 1.175–2.472 | 0.005 | 1.578 | 1.085–2.295 | 0.017 |
Major resection, yes vs. no | 1.553 | 1.186–2.033 | 0.001 |  |  |  |
Resection margin < 10 mm, yes vs. no | 1.833 | 1.134–2.963 | 0.012 |  |  |  |
Cirrhosis, yes vs. no | 0.854 | 0.623–1.171 | 0.327 |  |  |  |
Tumor diameter, cm | 1.117 | 1.074–1.162 | < 0.001 |  |  |  |
Multiple tumors, yes vs. no | 0.816 | 0.433–1.538 | 0.530 |  |  |  |
Satellite nodules, yes vs. no | 1.997 | 1.537–2.595 | < 0.001 | 1.448 | 1.095–1.915 | 0.009 |
Tumor capsule, yes vs. no | 0.620 | 0.421–0.914 | 0.016 |  |  |  |
Tumor differentiation, high vs. median vs. low | 1.410 | 0.809–2.458 | 0.225 |  |  |  |
Adjacent tissue invasion, yes vs. no | 1.570 | 0.944–2.611 | 0.082 |  |  |  |
MVI, yes vs. no | 1.794 | 1.254–2.566 | 0.001 | 1.587 | 1.101–2.291 | 0.014 |
LNM, yes vs. no | 2.179 | 1.618–2.935 | < 0.001 | 1.422 | 1.038–1.949 | 0.028 |
IFS, high vs. median vs. low | 2.320 | 1.955–2.753 | < 0.001 | 2.106 | 1.682–2.637 | < 0.001 |