Fig. 3

Comparison of genomic features. A Tumour mutation burden per megabase, B Tumour mutational load (log10), C microsatellite-instable indels per megabase, D structural variant burden, E expression score of IFN-gamma (IFN-γ) in patients experiencing clinical benefit (blue) or no clinical benefit (red), F expression score of IFN-γ in patients with two JAK1 (K860N/P430R) frameshift mutations (orange) or not (green) and G proportion of patients with two JAK1 (K860N/P430R) frameshift mutations or not, by clinical benefit. The box plot shows the median, first and third quartiles, whiskers extend to 1.5 times the interquartile range, and outlying points are plotted individually and two-sided. In A-F a two-sided Mann-Whitney U test was used. In G a Fisher’s Exact test was used *p < 0.05; ns, not significant