Table 1 Clinical characteristics of patients with pancreatic diseases and healthy controls in training and testing sets

Gender

 Male

187(55.3)

164(52.3)

25(26.0)

12(15.4)

27(57.4)

 Female

151(44.7)

149(47.6)

71(74.0)

66(84.6)

20(42.6)

Age

 ≤ 60

215(63.6)

205(65.4)

70(72.9)

70(89.7)

20(42.6)

 > 60

123(36.4)

103(34.5)

26(27.1)

8(10.3)

27(57.4)

CA199

 ≥ 37

240(71.0)

5(1.6)

13(13.5)

4(5.1)

2(4.3)

 < 37

98(29.0)

308(98.4)

83(86.5)

74(94.9)

45(95.7)

Location:

 Head

260(76.9)

23(24.0)

25(32.1)

13(27.7)

 Body or Tail

78(23.1)

73(76.0)

53(67.9)

34(72.3)

Tumor size

 > 4 cm

81(24.0)

40(41.6)

40(51.3)

16(34.0)

 ≤ 4 cm

257(76.0)

56(58.4)

38(48.7)

31(66.0)

Pathological type

 Ductal adenocarcinoma

308(91.1)

31(32.3; chronic pancreatitis)

 others

30(8.9)

65(67.7; adenoma)

Differentiation

 High and Moderate

218(64.5)

40(85.1; G1-G2)

 Poor

120(35.5)

7(14.94; G3)

Lymph nodes

 + 

107(31.7)

 -

231(68.3)

TNM stage

 I

166(49.1)

 II

172(50.9)

Fibrinogen(g/L)

3.44 ± 0.95

2.87 ± 0.56

2.76 ± 0.76

2.46 ± 0.69

2.54 ± 0.58

albumin(g/L)

38.52 ± 4.04

43.75 ± 2.38

39.62 ± 3.45

40.79 ± 3.72

40.69 ± 3.11

prealbumin(mg/L)

215.17 ± 69.86

322.74 ± 58.73

255.85 ± 61.72

239.98 ± 56.07

271.97 ± 65.09

neutrophil(× 10⁹/L)

3.95 ± 1.64

3.45 ± 1.05

3.41 ± 1.95

3.70 ± 1.47

3.45 ± 1.24

lymphocyte(× 10⁹/L)

1.62 ± 0.62

1.94 ± 0.56

2.03 ± 0.63

2.09 ± 0.54

1.98 ± 0.59

platelet(× 10⁹/L)

224.43 ± 69.06

238.48 ± 52.91

227.42 ± 67.02

248.58 ± 75.31

212.57 ± 51.78

monocyte(× 10⁹/L)

0.51 ± 0.19

0.37 ± 0.11

0.46 ± 0.19

0.52 ± 0.20

0.43 ± 0.16

AFR (Mean ± SD)

0.091 ± 0.03

0.066 ± 0.013

0.71 ± 0.02

0.061 ± 0.017

0.063 ± 0.01

APR (Mean ± SD)

0.019 ± 0.012

0.009 ± 0.003

0.011 ± 0.005

0.011 ± 0.006

0.009 ± 0.003

NLR (Mean ± SD)

2.78 ± 1.67

1.89 ± 0.74

1.81 ± 1.26

1.84 ± 0.77

1.87 ± 0.83

PLR (Mean ± SD)

156.32 ± 75.68

131.15 ± 45.19

119.15 ± 40.90

123.36 ± 42.09

115.21 ± 40.50

MLR (Mean ± SD)

0.36 ± 0.21

0.20 ± 0.06

0.24 ± 0.11

0.26 ± 0.10

0.23 ± 0.09

PNI (Mean ± SD)

46.62 ± 5.33

53.47 ± 3.81

49.79 ± 4.50

51.23 ± 4.92

50.59 ± 4.64

FLR (Mean ± SD)

2.46 ± 1.26

1.57 ± 0.54

1.47 ± 0.56

1.26 ± 0.51

1.38 ± 0.44

Gender

 Male

46(54.8)

46(58.2)

9(39.1)

4(20.0)

8(66.7)

 Female

38(45.2)

33(41.8)

14(60.9)

16(80.0)

4(33.3)

Age

 ≤ 60

44(52.4)

56(70.9)

13(56.6)

17(85.0)

7(58.3)

 > 60

40(47.6)

23(29.1)

10(43.4)

3(15.0)

5(41.7)

CA199

 ≥ 37

63(75.0)

2(2.6)

9(39.1)

1(5.0)

2(16.7)

 < 37

21(35.0)

77(97.4)

14(60.8)

19(95.0)

10(83.3)

Location:

 Head

58(69.0)

4(17.4)

5(25.0)

5(41.7)

 Body or Tail

34(31.0)

19(82.6)

15(75.0)

7(58.3)

Tumor size

 > 4 cm

21(44.7)

11(47.8)

11(55.0)

4(33.3)

 ≤ 4 cm

63(55.3)

12(52.2)

9(45.0)

8(66.7)

Pathological type

 Ductal adenocarcinoma

75(89.3)

8(34.7; chronic pancreatitis)

 others

9(10.7)

15(65.2; adenoma)

Differentiation

 High and Moderate

43(51.2)

10(83.3; G1-G2)

 Poor

41(48.8)

2(16.7; G3)

Lymph nodes

 + 

17(20.2)

 -

67(79.8)

TNM stage

 I

50(59.5)

 II

34(40.5)

Fibrinogen(g/L)

3.56 ± 0.94

2.82 ± 0.49

2.59 ± 0.58

2.42 ± 0.60

2.59 ± 0.69

albumin(g/L)

37.98 ± 3.07

43.78 ± 2.09

38.68 ± 3.23

40.54 ± 3.25

40.5 ± 3.28

prealbumin(mg/L)

212.73 ± 45.03

312.30 ± 57.40

269.65 ± 63.85

231.74 ± 55.87

280.17 ± 52.37

neutrophil(× 10⁹/L)

3.88 ± 1.26

3.46 ± 0.95

3.37 ± 1.24

3.24 ± 1.12

3.17 ± 1.15

lymphocyte(× 10⁹/L)

1.59 ± 0.45

2.01 ± 0.66

1.89 ± 0.44

2.05 ± 0.76

1.84 ± 0.42

platelet(× 10⁹/L)

234.04 ± 77.48

250.29 ± 61.98

234.26 ± 78.76

241.37 ± 49.04

198.08 ± 46.20

monocyte(× 10⁹/L)

0.49 ± 0.14

0.37 ± 0.10

0.42 ± 0.14

0.42 ± 0.13

0.40 ± 0.14

AFR (Mean ± SD)

0.095 ± 0.028

0.065 ± 0.01

0.067 ± 0.015

0.060 ± 0.015

0.064 ± 0.015

APR (Mean ± SD)

0.018 ± 0.009

0.009 ± 0.003

0.010 ± 0.003

0.011 ± 0.005

0.009 ± 0.002

NLR (Mean ± SD)

2.57 ± 0.85

1.85 ± 0.65

1.83 ± 0.72

1.73 ± 0.75

1.74 ± 0.59

PLR (Mean ± SD)

157.09 ± 60.35

133.85 ± 45.32

128.29 ± 49.03

135.00 ± 57.96

112.36 ± 34.29

MLR (Mean ± SD)

0.33 ± 0.13

0.20 ± 0.06

0.22 ± 0.06

0.24 ± 0.15

0.22 ± 0.07

PNI (Mean ± SD)

45.91 ± 3.88

53.83 ± 3.95

48.16 ± 4.11

50.78 ± 5.13

49.70 ± 4.67

FLR (Mean ± SD)

2.45 ± 0.97

1.55 ± 0.55

1.45 ± 0.50

1.34 ± 0.59

1.46 ± 0.47

Gender

 Male

5(62.5)

7(77.8)

6(54.5)

 Female

3(37.5)

2(22.2)

5(45.4)

Age

 ≤ 60

5(62.5)

6(66.7)

6(54.5)

 > 60

3(37.5)

3(33.3)

5(45.4)

CA199

 ≥ 37

6(75.0)

1(11.1)

1(9.1)

 < 37

2(25.0)

8(88.9)

10(90.9)

Location:

 Head

6(75.0)

4(36.4)

 Body or Tail

2(25.0)

7(63.6)

Tumor size

 > 4 cm

2(25.0)

5(45.5)

 ≤ 4 cm

6(75.0)

6(54.4)

Pathological type

 Ductal adenocarcinoma

7(87.5)

2(18.2; chronic pancreatitis)

7 (63.6; adenoma)

2(18.2, Solid pseudo papilloma)

 others

1(12.5)

Differentiation

 High and Moderate

5(62.5)

 Poor

3(37.5)

Lymph nodes

 + 

3(37.5)

 -

5(62.5)

TNM stage

 I

4(50.0)

 II

4(50.0)

Fibrinogen(g/L)

3.16 ± 0.55

2.55 ± 0.54

2.81 ± 0.52

albumin(g/L)

38.20 ± 3.08

40.83 ± 4.49

43.66 ± 3.62

prealbumin(mg/L)

205.25 ± 22.32

287.78 ± 15.70

278.72 ± 10.51

neutrophil(× 10⁹/L)

3.69 ± 0.86

2.97 ± 0.71

2.75 ± 0.71

lymphocyte(× 10⁹/L)

1.46 ± 0.34

1.95 ± 0.43

1.86 ± 0.54

platelet(× 10⁹/L)

192.5 ± 54.5

230.67 ± 48.95

237.24 ± 97.47

monocyte(× 10⁹/L)

0.48 ± 0.16

0.40 ± 0.16

0.36 ± 0.13

AFR (Mean ± SD)

0.082 ± 0.11

0.063 ± 0.015

0.65 ± 0.13

APR (Mean ± SD)

0.015 ± 0.002

0.009 ± 0.002

0.010 ± 0.002

NLR (Mean ± SD)

2.60 ± 0.73

1.58 ± 0.43

1.54 ± 0.44

PLR (Mean ± SD)

135.35 ± 40.17

121.40 ± 28.15

133.67 ± 54.68

MLR (Mean ± SD)

0.33 ± 0.81

0.20 ± 0.06

0.20 ± 0.07

PNI (Mean ± SD)

45.51 ± 3.58

50.57 ± 4.59

52.90 ± 4.44

FLR (Mean ± SD)

2.24 ± 0.56

1.35 ± 0.34

1.56 ± 0.32