Fig. 4

DVL2 depletion modulates Wnt and HER2 signaling cascades with or without in vitro HER2 inhibition. A, B Immunoblot analyses of lysates respectively from SKBR3 and BT474 cells stably expressing NTC vs. shDVL2 and treated with 1 nM neratinib (Nert) or DMSO control for 24 h and probed with antibodies as indicated with Tubulin as housekeeping control. Please also see Methods and Supplementary Table 1 for additional information