Table 3 Relationship between PKM2 expression and clinicopathological features of breast cancer patients with HR-ve versus HR + ve tumors
Parameters | HR -ve | HR + ve | ||||
|---|---|---|---|---|---|---|
Low PKM2 | High PKM2 | p-value | Low PKM2 | High PKM2 | p-value | |
Age (Years) | 51.88 ± 12.82 | 48.96 ± 11.78 | 0.929 | 53.08 ± 12.27 | 51.53 ± 9.54 | 0.575 |
Tumor grade I II III | 0 (0.0) 7 (16.7) 35 (83.3) | 0 (0.0) 2 (8.0) 23 (92.0) | 0.466 | 4 (11.1) 10 (27.8) 22 (61.1) | 3 (10.0) 14 (46.7) 13 (43.3) | 0.270 |
Tumor volume (cm 3 ) | 47.87 ± 67.56 | 66.64 ± 125.41 | 0.428 | 24.97 ± 34.89 | 34.28 ± 48.29 | 0.368 |
TNM Stage I II III IV | 1 (2.5) 14 (35.0) 14 (35.0) 11 (27.5) | 2 (8.0) 4 (16.0) 10 (40.0) 9 (36.0) | 0.297 | 3 (8.3) 10 (27.8) 11 (30.6) 12 (33.3) | 0 (0.0) 8 (27.6) 9 (31.0) 12 (41.4) | 0.532 |
TNM I/II III/IV | 15 (37.5) 25 (62.5) | 6 (24.0) 19 (76.0) | 0.290 | 13 (36.1) 23 (63.9) | 8 (27.6) 21 (72.4) | 0.595 |
T stage T1 T2 T3 T4 | 2 (4.8) 22 (52.4) 13 (31.0) 5 (11.9) | 3 (12.0) 11 (44.0) 9 (36.0) 2 (8.0) | 0.640 | 5 (13.9) 19 (52.8) 9 (25.0) 3 (8.3) | 0 (0.0) 18 (60.0) 10 (33.3) 2 (6.7) | 0.197 |
pT T1/T2 T3/T4 | 24 (57.1) 18 (42.9) | 14 (56.0) 11 (44.0) | 1.000 | 24 (66.7) 12 (33.3) | 18 (60.0) 12 (40.0) | 0.615 |
pN stage N0 N1 N2 N3 | 11 (28.2) 13 (33.3) 6 (15.4) 9 (23.1) | 7 (28.0) 2 (8.0) 6 (24.0) 10 (40.0) | 0.093 | 12 (34.3) 6 (17.1) 7 (20.0) 10 (28.6) | 8 (27.6) 9 (31.0) 6 (20.7) 6 (20.7) | 0.602 |
M stage M0 M1 | 29 (72.5) 11 (27.5) | 16 (64.0) 9 (36.0) | 0.583 | 24 (66.7) 12 (33.3) | 17 (58.6) 12 (41.4) | 0.607 |
Axillary lymph nodes metastasis Negative Positive | 11 (27.5) 29 (72.5) | 7 (28.0) 18 (72.0) | 1.000 | 12 (33.3) 24 (66.7) | 9 (30.0) 21 (70.0) | 0.797 |
Lymphatic/vascular invasion Negative Positive | 15 (38.5) 24 (61.5) | 6 (26.1) 17 (73.9) | 0.409 | 16 (45.7) 19 (54.3) | 7 (23.3) 23 (76.7) | 0.073 |
HER2 status Negative Positive | 11 (26.2) 31 (73.2) | 17 (68.0) 8 (32.0) | 0.001 | 7 (19.4) 29 (80.6) | 24 (80.0) 6 (20.0) | < 0.001 |
DCIS Absent Present | 8 (19.0) 34 (81.0) | 10 (43.5) 13 (56.5) | 0.046 | 7 (19.4) 29 (80.6) | 3 (10.0) 27 (90.0) | 0.327 |
Family History No Yes | 17 (70.8) 7 (29.2) | 15 (68.2) 7 (31.8) | 1.000 | 25 (78.1) 7 (21.9) | 26 (89.7) 3 (10.3) | 0.307 |
Ki-67 Low High | 19 (45.2) 23 (54.8) | 11 (44.0) 14 (56.0) | 1.000 | 24 (66.7) 12 (33.3) | 24 (80.0) 6 (20.0) | 0.275 |
SP Low High | 24 (57.1) 18 (42.9) | 17 (68.0) 8 (32.0) | 0.444 | 26 (72.2) 10 (27.8) | 12 (40.0) 18 (60.0) | 0.012 |
NK1R Low High | 26 (61.9) 16 (38.1) | 12 (48.0) 13 (52.0) | 0.314 | 24 (66.7) 12 (33.3) | 21 (70.0) 9 (30.0) | 0.797 |