From: Somatic mutation landscape in a cohort of meningiomas that have undergone grade progression
Patient | Initial WHO grade | Final WHO grade | Location | Variant | Chromosome |
---|---|---|---|---|---|
A | 2 | 3 | Convexity | TERT promoter ERCC1 | 5 19 |
B | 2 | 3 | Convexity | NF2:p.Phe94Ter TERT promoter SPTA1 NF1 | 22 5 1 17 |
C | 1 | 3 | Parasagittal | NF2:p.Arg57Ter POLE | 22 12 |
D | 1 | 3 | Sphenoid Wing | SETD2 NAB2-STAT6 PIK3C2B DNMT3B ABRAXAS1 IRF4 | 3 12 1 20 4 6 |
E | 1 | 2 | Convexity | NF2:p.Lys332SerfsTer14 CREBBP MST1 PNRC1 | 22 16 3 6 |
F | 1 | 2 | Sphenoid Wing | TSC2 | 16 |
G | 1 | 2 | Falcine CP angle | NF2:p.Ala323ProfsTer23 NF2:p.Glu342Ter NF2:p.Glu362ArgfsTer13 SF3B1 | 22 22 22 2 |
H | 1 | 2 | Convexity | IFNGR1 | 6 |
I | 1 | 2 | Sphenoid Wing | PTPN11 PIK3CA TRAF7 LATS2 GEN1 LRP1B | 12 3 16 13 2 2 |
J | 1 | 3 | Sphenoid Wing CP angle Spinal Cord | TP53 NAB2-STAT6 SPTA1 SLX4 CDK12 NKX3-1 | 17 12 1 16 17 8 |