Table 2 Association between PD-L1 genetic alterations and clinical/immunological characteristics in dMMR cohort and pMMR cohort
Characteristics | dMMR | pMMR | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Deletion | Disomy | Polysomy | Amplification | P | Adjusted P | *P | Disomy | Polysomy | Amplification | P | Adjusted P | |
Stage | Â | Â | Â | Â | 0.020 | 0.16 | 0.046 | Â | Â | Â | 0.189 | 1.512 |
I | 0 (0%) | 24 (16.3%) | 0 (0%) | 0 (0%) | Â | Â | Â | 24 (16.7%) | 0 (0%)) | 1 (12.5%) | Â | Â |
II | 3 (42.9%) | 83 (56.5%) | 2 (50%) | 0 (0%) | Â | Â | Â | 82 (56.9%) | 6 (50%) | 3 (37.5%) | Â | Â |
III | 2 (28.6%) | 34 (23.1%) | 2 (50%) | 1 (50%) | Â | Â | Â | 34 (23.6%) | 6 (50%) | 3 (37.5%) | Â | Â |
IV | 2 (28.6%) | 6 (4.1%) | 0 (0%) | 1 (50%) | Â | Â | Â | 4 (2.9%) | 0 (0%) | 1 (12.5%) | Â | Â |
PD1 | Â | Â | Â | Â | 0.002 | 0.016 | 0.046 | Â | Â | Â | 0.414 | 7.87 |
Negative | 7 (100%) | 98 (66.7%) | 0 (0%) | 0 (0%) | Â | Â | Â | 71 (49.3%) | 8 (66.7%) | 5 (62.5%) | Â | Â |
Positive | 0 (0%) | 49 (33.3%) | 4 (100%) | 2 (100%) | Â | Â | Â | 73 (50.7%) | 4 (33.3%) | 3 (37.5%) | Â | Â |
PDL1 (ICs) |  |  |  |  | 0.006 | 0.048 | 0.071 |  |  |  | < 0.001 | < 0.001 |
Negative | 3 (42.9%) | 118 (80.3%) | 3 (75.0%) | 0 (0%) | Â | Â | Â | 100 (69.4%) | 0 (0%) | 0 (0%) | Â | Â |
Positive | 4 (57.1%) | 29 (19.7%) | 1 (25%) | 2 (100%) | Â | Â | Â | 44 (30.6%) | 12 (100%) | 8 (100%) | Â | Â |
PDL1 (TCs) |  |  |  |  | < 0.001 | < 0.001 | < 0.001 |  |  |  | < 0.001 | < 0.001 |
Negative | 7 (100%) | 121 (82.3%) | 2 (50%) | 0 (0%) | Â | Â | Â | 127 (88.2%) | 3 (25.0%) | 0 (0%) | Â | Â |
Positive | 0 (0%) | 26 (17.7%) | 2 (50%) | 2(100%) | Â | Â | Â | 17 (11.8%) | 9 (75.0%) | 8 (100%) | Â | Â |
CD4 + T cell |  |  |  |  | 0.004 | 0.032 | 0.083 |  |  |  | 0.182 | 3.46 |
Negative | 0 (0%) | 79 (53.7%) | 4 (100%) | 2 (100%) | Â | Â | Â | 48 (33.3%) | 7 (58.3%) | 2 (25.0%) | Â | Â |
Positive | 7 (100%) | 68 (46.3%) | 0 (0%) | 0 (0%) | Â | Â | Â | 96 (66.7%) | 5 (41.7%) | 6 (75.0%) | Â | Â |
CD8 + T cell |  |  |  |  | 0.004 | 0.032 | 0.064 |  |  |  | 0.172 | 3.27 |
Negative | 0 (0%) | 78 (53.1%) | 4 (100%) | 2 (100%) | Â | Â | Â | 74 (51.4%) | 3 (25.0%) | 3 (37.5%) | Â | Â |
Positive | 7 (100%) | 69 (46.9%) | 0 (0%) | 0 (0%) | Â | Â | Â | 70 (48.6%) | 9 (75.0%) | 5 (62.5%) | Â | Â |
CD68 | Â | Â | Â | Â | 0.005 | 0.040 | 0.012 | Â | Â | Â | 0.383 | 7.28 |
Negative | 7 (100%) | 78 (53.1%) | 0 (0%) | 0 (0%) | Â | Â | Â | 74 (51.4%) | 4 (25.0%) | 3 (37.5%) | Â | Â |
Positive | 0 (0%) | 69 (46.9%) | 4 (100%) | 2 (100%) | Â | Â | Â | 70 (48.6%) | 8 (75.0%) | 5 (62.5%) | Â | Â |
NK cell | Â | Â | Â | Â | 0.907 | 17.23 | Â | Â | Â | Â | 0.507 | 9.63 |
Negative | 7 (100%) | 141 (95.6%) | 4 (100%) | 2 (100%) | Â | Â | Â | 135 (93.8%) | 12(100.%) | 7 (87.5%) | Â | Â |
Positive | 0 (0%) | 6 (4.1%) | 0 (0%) | 0 (0%) | Â | Â | Â | 9 (6.3%) | 0 (0%) | 1 (12.5%) | Â | Â |