Table 1 Association between PD-L1 genetic alterations and immunological characteristics
Characteristics | All, Number (%) | Deletion Number (%) | Disomy, Number (%) | Polysomy, Number (%) | Amplification,Number (%) | P | Adjusted P | *P |
|---|---|---|---|---|---|---|---|---|
PD1 | Â | Â | Â | Â | Â | 0.257 | 5.14 | Â |
Negative | 157(48.5%) | 6 (85.7%) | 138 (47.4%) | 8 (50.0%) | 5 (50.0%) | Â | Â | Â |
Positive | 167 (51.5%) | 1 (14.3%) | 153 (52.6%) | 8 (50.0%) | 5 (50.0%) | Â | Â | Â |
PDL1 (ICs) |  |  |  |  |  | < 0.001 | < 0.001 | < 0.001 |
Negative | 224 (69.1%) | 3 (42.9%) | 218 (74.9%) | 3 (18.8%) | 0 (0%) | Â | Â | Â |
Positive | 100 (30.9%) | 4 (57.1%) | 73 (25.1%) | 13 (81.3%) | 10 (100%) | Â | Â | Â |
PDL1 (TCs) |  |  |  |  |  | < 0.001 | < 0.001 | < 0.001 |
Negative | 258 (79.6%) | 7 (100.0%) | 248 (85.2%) | 4 (18.8%) | 0 (0%) | Â | Â | Â |
Positive | 66 (20.4%) | 0 (0.0%) | 43 (14.8%) | 12 (81.3%) | 10 (100%) | Â | Â | Â |
CD4 + T cell |  |  |  |  |  | 0.023 | 0.46 |  |
Negative | 142 (43.8%) | 0 (0%) | 127 (43.6%) | 11 (68.8%) | 4 (40.0%) | Â | Â | Â |
Positive | 182 (56.2%) | 7 (100%) | 164 (56.4%) | 5 (31.3%) | 6 (60.0%) | Â | Â | Â |
CD8 + T cell |  |  |  |  |  | 0.048 | 0.96 |  |
Negative | 165 (50.9%) | 0 (0%) | 152 (52.2%) | 7 (43.8%) | 5 (50.0%) | Â | Â | Â |
Positive | 159 (49.1%) | 7 (100%) | 139 (47.8%) | 9 (56.3%) | 5 (50.0%) | Â | Â | Â |
CD68 | Â | Â | Â | Â | Â | 0.005 | 0.1 | 0.049 |
Negative | 166 (51.2%) | 7 (100%) | 152 (52.2%) | 4 (25.0%) | 3 (30.0%) | Â | Â | Â |
Positive | 158 (48.8%) | 0 (0%) | 139 (47.8%) | 12 (75.0%) | 7 (70.0%) | Â | Â | Â |
NK cell | Â | Â | Â | Â | Â | 0.622 | 12.44 | Â |
Negative | 308 (95.1%) | 7 (100%) | 276 (94.8%) | 16 (100%) | 9 (90%) | Â | Â | Â |
Positive | 16 (4.9%) | 0 (0) | 15 (5.2%) | 0 (0%) | 1 (10.0%) | Â | Â | Â |