Table 1 Baseline characteristics and clinical variables between nonmetastatic gallbladder cancer and cholecystitis

Baseline characteristics

Age

65.06 ± 8.34

59.06 ± 12.25

0.019^b

Sex

40:48

26:8

0.002

(Male:Female, n, %)

45.5%:54.5%

76.5%:23.5%

BMI

24.46 ± 2.93

23.70 ± 2.93

0.204^a

Smoking history (n, %)

13 (14.8%)

16 (47.1%)

0.001

Drinking history (n, %)

7 (8.0%)

8 (23.5%)

0.029

Clinical variables

Medical history (n, %)

Cholecystitis

3 (3.4%)

5 (14.7%)

0.038

Cholecystolithiasis

9 (10.2%)

15 (44.1%)

 < 0.001

Gallbladder polyps

4 (4.5%)

0 (0.0%)

0.575

Major signs (n, %)

Jaundice

14 (15.9%)

9 (26.5%)

0.202

Fever

1 (1.1%)

7 (20.6%)

0.001

Abdominal pain

41 (46.6%)

21 (61.8%)

0.160

Abdominal mass

0 (0.0%)

0 (0.0%)

-

Laboratory examination

WBC (10⁹/L)

6.96 ± 3.09

6.25 ± 2.30

0.249^b

LYM

0.27 ± 0.10

0.27 ± 0.10

0.924^b

NEUT

0.62 ± 0.12

0.63 ± 0.11

0.714^b

CEA (ng/ml)

21.73 ± 69.50

2.32 ± 1.52

0.001^b

CEA > 5 ng/ml

32 (36.4%)

2 (5.9%)

0.001

CA19-9 (U/mL)

937.86 ± 2942.96

1009.54 ± 3562.21

0.910^a

CA19-9 > 37 U/mL

48 (54.5%)

16 (47.1%)

0.545

Histologic type (n, %)

Adenocarcinoma

78 (89%)

Acute cholecystitis

17 (50%)

Squamous cell carcinoma

1 (1%)

Chronic cholecystitis

13 (38%)

Adenosquamous carcinoma

2 (2%)

XGC

4 (12%)

Others

7 (8%)