Table 2 Univariate and multivariate analysis of demographic and clinical characteristics that correlate with OS of gliomas patients (TCGA database)
From: HELLPAR/RRM2 axis related to HMMR as novel prognostic biomarker in gliomas
Characteristics | Total(N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
WHO grade | 634 | Â | Â | Â | Â |
 G2 | 223 | Reference |  |  |  |
 G3 | 243 | 2.999 (2.007–4.480) |  < 0.001 | 1.694 (1.088–2.636) | 0.020 |
 G4 | 168 | 18.615 (12.460–27.812) |  < 0.001 | 3.802 (2.200–6.569) |  < 0.001 |
1p/19q codeletion | 688 | Â | Â | Â | Â |
 codel | 170 | Reference |  |  |  |
 non-codel | 518 | 4.428 (2.885–6.799) |  < 0.001 | 1.486 (0.900–2.455) | 0.122 |
Age | 695 | Â | Â | Â | Â |
  <  = 60 | 552 | Reference |  |  |  |
  > 60 | 143 | 4.668 (3.598–6.056) |  < 0.001 | 1.530 (1.124–2.081) | 0.007 |
Gender | 695 | Â | Â | Â | Â |
 Female | 297 | Reference |  |  |  |
 Male | 398 | 1.262 (0.988–1.610) | 0.062 | 1.213 (0.923–1.595) | 0.166 |
IDH status | 685 | Â | Â | Â | Â |
 WT | 246 | Reference |  |  |  |
 Mut | 439 | 0.117 (0.090–0.152) |  < 0.001 | 0.314 (0.209–0.473) |  < 0.001 |
HMMR | 695 | Â | Â | Â | Â |
 Low | 348 | Reference |  |  |  |
 High | 347 | 4.344 (3.264–5.780) |  < 0.001 | 1.650 (1.147–2.372) | 0.007 |