Table 6 Performance of MMP14 expression as a predictor of extranodal extension
MMP14 expression | Sensitivity | Specificity | PPN | NPV | Accuracy | AUC | 95% CI | p-value | Cohort proportion (no.; yes:no) |
|---|---|---|---|---|---|---|---|---|---|
Surgically resected specimens | |||||||||
CAFs (positive) | 78% | 59% | 46% | 81% | 66% | 0.684 | 0.576–0.793 | < 0.001 | (39:32) |
Tumour nest (high) | 78% | 68% | 60% | 83% | 72% | 0.730 | 0.6238–0.8358 | < 0.01 | (35:36) |
Co-scoring system (high risk) | 63% | 84% | 71% | 79% | 76% | 0.735 | 0.628–0.843 | < 0.01 | (24:47) |
Biopsy specimens | Â | Â | Â | ||||||
CAFs (positive) | 90% | 72% | 47% | 96% | 76% | 0.811 | 0.688–0.934 | < 0.001 | (19:27) |
tumour nest (high) | 80% | 72% | 42% | 93% | 72% | 0.747 | 0.596–0.899 | 0.01 | (19:27) |
Co-scoring system (high-risk) | 80% | 89% | 67% | 94% | 87% | 0.844 | 0.704–0.985 | < 0.01 | (12:34) |