Table 5 Bivariate and multivariate logistic regression analyses of ENE using surgically resected and biopsy specimens

Resection specimens (n = 71)

pT3,4

6.466

1.346–31.058

0.011

-

-

-

0.230

pDOI > 10 mm

3.620

1.066–12.299

0.033

-

-

-

0.508

Invasion pattern

1.603

0.288–8.906

0.587

-

-

-

-

DR-I

3.046

0.972–9.543

0.050

-

-

-

-

TB-H

3.429

1.205–9.753

0.018

-

-

-

-

TILs-L

1.552

0.583–4.135

0.378

-

-

-

-

MMP14 at the tumour nest (high)

7.500

2.479–22.691

< 0.001

-

-

-

0.058

MMP14 in CAFs (positive)

5.056

1.703–15.011

< 0.01

-

-

-

0.536

MMP14 co-scoring system (high-risk)

8.986

2.921–27.642

< 0.001

0.573

8.986

2.921–27.642

< 0.001

Biopsy specimens (n = 46)

cDOI > 10 mm

7.200

0.824–62.937

0.046

-

-

-

0.183

DR-I

5.727

0.653–50.258

0.09

-

-

-

-

TB-H

2.000

0.458–8.725

0.35

-

-

-

-

TILs-L

0.250

0.047–1.344

0.09

-

-

-

-

MMP14 at the tumour nest (high)

9.091

1.654–49.965

< 0.01

-

-

-

0.458

MMP14 in CAFs (positive)

23.400

2.626-209.279

< 0.001

-

-

-

0.289

MMP14 co-scoring system (high-risk)

32.0000

4.953-206.762

< 0.001

0.952

32.000

4.953-206.761

< 0.001