MMP14 expression levels accurately predict the presence of extranodal extensions in oral squamous cell carcinoma: a retrospective cohort study

Table 4 Association of clinicopathological features with MMP14 expression in the tumour nest and CAFs of 46 OSCC biopsy specimens

	MMP14 expression in CAFs at the TSI (biopsies)			MMP14 expression in the tumour nest at the TSI (biopsies)			MMP14 co-scoring system (biopsies)
	Negative	Positive	p	Low	High	p	Low- risk	High- risk	p
pT			*0.01*			*0.01*			0.05
1.2	12	2		12	2		13	1
3.4	15	17		15	17		21	11
cDOI			*0.01*			0.17			0.08
≤ 10 mm	14	3		12	5		15	2
> 10 mm	13	16		15	14		19	10
Lymph node metastasis			*< 0.01*			*< 0.01*			*< 0.001*
(-)	19	4		19	4		23	0
(+)	8	15		8	15		11	12
pN			*< 0.01*			*0.03*			*< 0.001*
0,1	23	9		22	10		28	4
2,3	4	10		5	9		6	8
ENE			*< 0.001*			*< 0.01*			*< 0.001*
(-)	26	10		25	11		32	4
(+)	1	9		2	8		2	8
Differentiation			0.58			0.58			0.58
Well	20	14		14	14		19	9
Moderate	6	5		11	5		13	3
Poor	1	0		2	0		2	0
Invasion formation			0.11			0.45			0.28
1.2	4	0		3	1		4	0
3.4c.4d	23	19		24	18		30	12
DR			0.33			*0.04*			*0.04*
Mature	10	5		12	3		14	1
Immature	17	14		15	16		20	11
TB			0.24			0.11			0.09
Low	14	7		15	6		18	3
High	13	12		12	13		16	9
TILs			*0.03*			*0.01*			*0.01*
High	14	4		15	3		17	1
Low	13	15		12	16		17	11

CAFs, cancer-associated fibroblasts; OSCC, oral squamous cell carcinoma; TSI, tumour–stromal interface; pT, pathological T; pDOI, pathological depth of invasion; pN, pathological N; DR, depth of invasion; TB, tumour budding; TILs, tumour-infiltrating lymphocytes; Ly, lymphatic invasion; V, vascular invasion; p, p-value; Pn, perineural invasion. Boldface indicates statistically significant values

ISSN: 1471-2407