Fig. 5

Five-year overall survival of patients with OSCC who underwent 71 resections and 46 biopsies in whom ENE was absent or present and for whom the MMP14 co-scoring system indicated high risk or low risk

In 71 resected patients with or without ENE (a) and at high risk or low risk according to the MMP14 co-scoring system (b). In 46 patients also evaluated by biopsies with or without ENE (c) and at high risk or low risk according to the MMP14 co-scoring system (d). Notably, patients with ENE and at high-risk according to the MMP14 co-scoring system had significantly worse prognosis in both resection and biopsies