Fig. 5

1,5-AG promoted leukemic progression in a xenotransplantation mouse model. A Schematic representation of the experimental design process and grouping. B Detection of 1,5-AG in the peripheral blood of mice on day 7 in different groups was performed by liquid chromatography-mass spectrometry. C In vivo leukemia burden in mice from different groups using the In Vivo Imaging System (IVIS). D–E Statistical analysis of IVIS in different groups of mice using GraphPad software. F–G Pre-B ALL mice were grouped and treated with 1,5-AG or N-acetylcysteine. Photographs of the spleen of each mouse in the different groups on day 7 are shown, and weights were statistically analyzed. H–I Infiltration of leukemia cells in the peripheral blood for different groups on day 7 was analyzed by flow cytometry. Data are presented as means ± standard deviations (n = 5/group). ns (P ≥ 0.05), ^*P < 0.05, ^**P < 0.01, ^***P < 0.001