Fig. 5
From: Combined anti-C1-INH and radiotherapy against glioblastoma
A Experimental setup in animals with subcutaneous tumors (image created with BioRender). B In the subcutaneous setting, treatment with combined RT + anti-C1-INH resulted in significantly prolonged survival and long-term anti-tumor control compared to non-treated control animals. C Combined treatment with RT + anti-C1-INH also significantly reduced tumor size, as seen on day 42 after tumor cell inoculations compared to non-treated control animals; the last day when all animals were still represented in each group. After day 42, animals had to be euthanized due to the size of the subcutaneous tumors exceeding 30 mm as defined in ethics regulations