Table 1 Baseline characteristics of study population

Index diagnosis

Age at cancer diagnosis, years

7.3 (3.7–12.1)

Age at end first pregnancy, years

27.0 (23.0–29.0)

Index diagnosis

 Leukemia

17 (43.6%)

 Lymphoma

5 (12.8%)

 Sarcoma

8 (20.5%)

 Aplastic anemia

6 (15.4%)

 Homozygous beta-thalassemia

2 (5.1%)

 Wilms’ tumor

1 (2.6%)

Treatment

Doxorubicin treatment

29 (74.4%)

 Equivalent cumulative dosage, mg/m²

270 (168–356)

Antimetabolites

15 (38.5%)

Alkylating agents

35 (89.7%)

Platinum-based agents

4 (10.3%)

Methotrexate

19 (48.7%)

Radiotherapy, any

11 (28.2%)

Total body irradiation

4 (10.3)

Thoracic radiotherapy

7 (17.9%)

 Dosage, gray

12 (5–36)

Abdominal radiotherapy

5 (12.8%)

Brain radiotherapy

7 (17.9%)

Neck radiotherapy

10 (25.6%)

Other risk factors

Heart failure risk score*

5 (4–7)

 Low risk (< 3)

4 (10.3%)

 Medium risk (3–5)

19 (48.7%)

 High risk (> 5)

16 (41.0%)

History of cardiotoxicity

5 (12.8%)

History of heart failure

1 (2.6%)

Smoking status prior to first pregnancy

 Never smoked

32 (82.1%)

 Stopped smoking

6 (15.4%)

 Active smoker

1 (2.6%)

Family history of premature cardiovascular disease

7 (17.9%)

Betablocker use up to 1st trimester of 1st pregnancy

3 (7.7%)