Table 5 Ki67 and perforin density associated with tumour-immune phenotypes

Immune cell markers:

 Immune topography T-cells (CD3/CD4)

  hot

26

8

18

0.102

26

9

17

0.049

  cold

29

17

12

28

19

9

  excluded

37

19

18

35

17

18

 Immune topography T-cells (CD3/CD8)

  hot

27

7

20

0.025

26

7

19

0.006

  cold

31

18

13

30

21

9

  excluded

34

19

15

33

17

16

 Immune topography B-cells (CD79A)

  hot

9

3

6

0.317

8

5

3

0.504

  cold

7

5

2

6

4

2

  excluded

80

39

41

78

37

41

 Immune topography macrophages (CD68/CD163)

  hot

27

11

16

0.224

27

12

15

0.165

  cold

29

18

11

28

18

10

  excluded

38

17

21

36

15

21

 Immune topography all immune cells

  hot

28

8

20

0.039

27

11

16

0.292

  cold

32

16

16

31

19

12

  excluded

31

19

12

30

15

15