Fig. 5
From: Characterisation of tumour-immune phenotypes and PD-L1 positivity in squamous bladder cancer
Perforin predicts overall survival (OS) in squamous bladder cancer depending on the extent of cytotoxic T-cell infiltrate. Univariate Kaplan–Meier survival curves are shown for perforin in tumours with low/high densities of T-cell markers CD3 (A-B), CD4 (C-D) and CD8 (E–F). Median cell densities of the overall sample were used as a threshold for low and high densities for each marker (CD3: 582.3 per mm2; CD4: 141.5 per mm2; CD8: 291.6 per mm2; Perforin: 9.0 per mm2). Vertical lines: censored cases