Table 1 GO and KEGG enrichment analysis of CD276 and their interactors
Ontology | ID | Description | GeneRatio | Genes | pvalue | p.adjust | qvalue |
|---|---|---|---|---|---|---|---|
BP | GO:0032729 | positive regulation of interferon-gamma production | 4/30 | HRAS, LGALS9, TNF, CD276 | 3.43e-06 | 0.004 | 0.003 |
BP | GO:0032649 | regulation of interferon-gamma production | 4/30 | HRAS, LGALS9, TNF, CD276 | 1.98e-05 | 0.010 | 0.007 |
BP | GO:0032609 | interferon-gamma production | 4/30 | HRAS, LGALS9, TNF, CD276 | 3.09e-05 | 0.010 | 0.007 |
CC | GO:0005925 | focal adhesion | 5/33 | CD9, ITGB5, TRIOBP, MPRIP, FBLIM1 | 5.27e-04 | 0.014 | 0.012 |
CC | GO:0005924 | cell-substrate adherens junction | 5/33 | CD9, ITGB5, TRIOBP, MPRIP, FBLIM1 | 5.45e-04 | 0.014 | 0.012 |
CC | GO:0030055 | cell-substrate junction | 5/33 | CD9, ITGB5, TRIOBP, MPRIP, FBLIM1 | 5.70e-04 | 0.014 | 0.012 |
MF | GO:0005178 | integrin binding | 3/31 | CD9, ITGB5, LGALS8 | 0.002 | 0.091 | 0.076 |
MF | GO:0050839 | cell adhesion molecule binding | 5/31 | CD9, ITGB5, LGALS8, TRIM25, MPRIP | 0.002 | 0.091 | 0.076 |
KEGG | hsa04510 | Focal adhesion | 4/14 | ELK1, HRAS, ITGA9, ITGB5 | 3.06e-04 | 0.018 | 0.013 |
KEGG | hsa05205 | Proteoglycans in cancer | 4/14 | ELK1, HRAS, ITGB5, TNF | 3.30e-04 | 0.018 | 0.013 |
KEGG | hsa05410 | Hypertrophic cardiomyopathy | 3/14 | ITGA9, ITGB5, TNF | 4.46e-04 | 0.018 | 0.013 |