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Fig. 8 | BMC Cancer

Fig. 8

From: Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development

Fig. 8

Knockdown of SETD1A suppresses OV cell tumorigenesis. A,B The tumor size A and weight B in SETD1A knockdown and control SKOV3 xenograft tumor (n = 6 per group). Unpaired two-tailed t-test. Data are expressed as mean ± SD. ****p < 0.0001. C The numbers of Ki67-positive tumor cell in SETD1A knockdown and control SKOV3 xenograft tumor tissue sections analyzed by IHC staining. Unpaired two-tailed t-test. Data are expressed as mean ± SD. ***p < 0.001. D The mRNA levels of Notch target genes, including Hes1, Hey1, Hey2, and Heyl in SETD1A knockdown and control SKOV3 xenograft tumor. Unpaired two-tailed t-test. Data are expressed as mean ± SD. ** p < 0.01, ***p < 0.001. E The proposed model of SETD1A promoting OV development

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BMC Cancer

ISSN: 1471-2407

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