Skip to main content
Fig. 5 | BMC Cancer

Fig. 5

From: Histone methyltransferase SETD1A interacts with notch and promotes notch transactivation to augment ovarian cancer development

Fig. 5

SETD1A interacts with Notch to initiate Notch signaling. A SETD1A assisted NICD in enhancing the reporter activity of the Hes1 promoter. Unpaired two-tailed t-test. Data are expressed as mean ± SD. ***p < 0.001, ****p < 0.0001. B,C Knockdown of SETD1A significantly decreases Hes1 promoter activity in SKOV3 B and Caov3 C cells. Unpaired two-tailed t-test. Data are expressed as mean ± SD. ***p < 0.001. D The ectopic interaction between Flag-SETD1A and Notch1-HA in HEK293T cells analyzed by co-IP analysis. E,F The endogenous interaction between SETD1A and Notch1 in SKOV3 E and Caov3 F cells analyzed by co-IP analysis

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us