Fig. 1

Treatment sequences showed by Sankey diagram [41, 33, 34]. Notes: 12 patients without any documented treatment were excluded from treatment pattern analysis. Lines ending without declarations of treatment represent patients who were not treated any further. Multiple treatment options per patient are possible. Abbreviations: CTx, chemotherapy; ER, endoscopic resection; LDT, liver directed therapy (radiofrequency ablation [RFA], selective internal radiation therapy [SIRT], transarterial [chemo-] embolization [TA(C)E]); mTOR, mTOR-inhibitors; PRRT, peptide receptor radionucleotide therapy; RT, radiotherapy; SSA, somatostatin analogues; SX, surgery; TKI, tyrosine kinase inhibitor; WW, watchful waiting