Fig. 4

Downregulation of IGF-1R expression or inhibition of IGF-1R activation increases sorafenib toxicity to HCC cells. (A, B) JC-1 was analyzed to reflect the level of apoptosis in each group by detecting the changes of mitochondrial membrane potential (×200). (C, D) AO/EB staining was used to detect the level of apoptosis in each treatment group (×200)