Table 7 Multiple logistic regression analysis predicting pathogenic mutation on breast cancers
Variable | Odds ratio | 95%CI | P value |
|---|---|---|---|
Age | |||
  < 40 years | Reference | NA | 0.418 |
  ≥ 40 years | 0.914 | 0.736–1.134 | |
Recurrence or Metastasis | |||
 No | Reference | NA | 0.039 |
 Yes | 1.402 | 1.024–1.916 | |
Biologic feature | |||
 unfavorable | Reference | NA | 0.000 |
 Intermediate/ favorable | 0.409 | 0.259–0.647 | |
Nuclear grade | |||
 Low/Intermediate | Reference | NA | 0.045 |
 high | 0.736 | 0.551–0.986 | |
ER | |||
 ER +  | Reference | NA | 0.416 |
 ER- | 1.368 | 0.646–2.896 | |
PR | |||
 PR +  | Reference | NA | 0.304 |
 PR- | 1.399 | 0.742–2.642 | |
Molecular substype | |||
 Non-Triple negative | Reference | NA | 0.634 |
 Triple negative | 1.099 | 0.721–1.676 | |
Breast density | |||
 Non-dense | Reference | NA | 0.005 |
 Dense | 1.315 | 1.093–1.582 | |
MRI Lesion type | |||
 Nonmass | Reference | NA | 0.000 |
 Mass | 2.705 | 1.739–4.207 | |
Internal enhancement pattern | |||
 Other enhancement types | Reference | NA | 0.004 |
 Rim mass-enhancement | 1.404 | 1.121–1.758 | |
Spiculated margin | |||
 Yes | Reference | NA | 0.049 |
 No | 0.803 | 0.649–0.994 | |
Central necrosis | |||
 No | Reference | NA | 0.388 |
 Yes | 0.875 | 0.649–1.181 | |